Current Research Highlights/News & Results

Alcohol and Substance Use Disorders:

• CDMRP-Funded Research Investigates Potential Treatment for the Co-Occurrence of PTSD and Alcohol Use Disorder
• PASA Awards Five Alcohol and Substance Use Disorders Research Projects
• PASA Awards Four Alcohol and Substance Use Disorders Research Projects

Alzheimer's:

• CDMRP-Funded Research Supports Early Detection of Alzheimer's Disease and Related Dementias
• Unraveling Links Between Cholesterol Markers and Cognitive Decline in Alzheimer's Disease
• Sound wave technologies: Transforming the future of clinical biofluidic diagnosis
• Neural Imaging and Machine Learning Approaches to Estimate Brain Age and Post-TBI Decline
• Human-Specific Circular RNAs as Key Players to Tauopathy?
• Telehealth-Based Mind-Body Interventions to Improve Cognition and Quality of Life in Individuals with MCI and Their Caregivers
• Detecting and Diagnosing Different Strains of Neurodegenerative Disease
• Improving Quality of Life Through Training to Reduce Care-Resistant Behaviors
• Understanding Long-Term TBI Consequences Using Artificial Intelligence
• Alzheimer's Effect on Financial Outcomes in the Period Prior to Clinical Diagnosis

Amyotrophic Lateral Sclerosis:

• CDMRP Supports Critical Developments in ALS, a Disease Associated with Military Service
• Using Machine Learning for Drug Repurposing to Impact ALS Treatment
• The Therapeutic Potential of Metformin in ALS: Moving Through the ALSRP Pipeline from Therapeutic Development Award (TDA) to Pilot Clinical Trial Award (PCTA)
• Amyotrophic Lateral Sclerosis Research Program Recognized for Including Consumer Reviewers in Two-Tier Review System
• New Nerve-on-a-Chip^® System Could Revolutionize Therapeutic Development for ALS
• A Combined Cell and Gene Therapy Approach for Preserving Motor Neuron Function in ALS
• UPDATE: ALS Treatment, Tegoprubart, Advancing Through Clinical Trials
• A New Compound to Prevent Motor Neuron Toxicity in ALS Enters Clinical Trial
• In Vivo Imaging and Novel Therapeutic Approaches in ALS
• A Challenge Best Tackled Together - Bridging the ALS Therapeutic Gap with Industry Partners
• Novel Metabolic Mechanism Implicated in an Early-Onset Form of Amyotrophic Lateral Sclerosis
• Novel ALS therapeutic intervention shows promise in preclinical trials

Autism:

• A Multidisciplinary Intervention for Encopresis in Children With ASD
• The Influence of Social, Educational, and Work Experiences on Psychological Health for Transition-Aged Youth with Autism Spectrum Disorders
• School-Based Intervention Programs for Children with ASD
• Autism Associated Mutations Impact on Ca2+ Channels and Behavior
• Flame Retardant Exposure During Early Development and Autism Spectrum Disorder
• Using Propranolol to Treat the Core Symptoms of Autism Spectrum Disorder
• Prenatal Polyunsaturated Fatty Acid Levels and Risk of Autism Spectrum Disorders
• A Clinical Trial of a Commercially Available Intervention in Pediatric Patients with Autism Spectrum Disorder and Moderate Language Delays
• The Development of Novel Drugs to Treat the Core Symptoms of ASD
• Evidence-Based Social-Emotional Therapy Using Augmented and Virtual Reality on Google Glass to Improve Employability and Job Skills in Adults with Autism

Bone Marrow Failure:

• Novel RNA-Based Aptamer Strategy to Correct Irregular DNA Methylation and Restore Vital Gene Functions in Myelodysplastic Syndromes
• The Role of Nemo-Like Kinase in the Pathogenesis and Treatment of Diamond-Blackfan Anemia
• Therapeutic Targeting of Spliceosomal-Mutant Acquired Bone Marrow Failure Disorders

Breast Cancer:

• CDMRP Advances Breast Cancer Care for Military Members and their Families
• Kara Kenan - Cancer does not Happen in a Void (Watch on YouTube
  Text Version
• CDMRP-FUNDED RESEARCH AIMS TO EFFICIENTLY DETECT BREAST CANCER
• Identification of Actionable Networks Promoting Breast Cancer Progression and Brain Metastasis
• Inhibition of Myeloid-Derived Suppressor Cell Biogenesis to Improve the Efficacy of Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
• Epigenetic Factor CECR2 as a Potential Target in Breast Cancer Metastasis
• The CDMRP Remembers Dr. Susan Love
• Dual-Loading Antibody-Drug Conjugates for Combating Breast Cancer Tumor Heterogeneity and Drug Resistance
• Functional Mechanism and Targeting of Metadherin in Breast Cancer
• Targeting GM-CSF to Inhibit Development of Leptomeningeal Disease from Breast Cancer
• A Novel Tubulin Inhibitor to Overcome Taxane Resistance in Metastatic Breast Cancer
• Tumor-Specific Fluorescence-Guided Surgery for Breast Cancer
• Overcoming HER2-Based Therapy Resistance in Breast Cancer Brain Metastases through CDK4/6 Inhibition
• Predicting Paclitaxel Sensitivity in Breast Cancer Patients
• Targeting Drug Resistance in Triple-Negative Breast Cancer
• Investigating Estrogen Receptor Mutations in Breast Cancer to Guide New Therapeutic Strategies
• Targeting Prolyl Peptidases in Triple-Negative Breast Cancer
• Identifying a Gene Panel to Predict Risk of Recurrence in Patients with Basal-Like Breast Cancer
• Targeting Senescence May Prevent Chemotherapy-Induced Bone Loss in Breast Cancer Patients
• Stromal Lysyl Hydroxylase 2, a Novel Biomarker for Breast Cancer Patient Prognosis
• Cluster of Differentiation 73 (CD73) Blockade Promotes Dendritic Cell Infiltration of Primary Tumors and Activation of Antitumor Immune Responses
• Mitochondria-Targeted Copper-Depleting Nanoparticle Inhibits Triple-Negative Breast Cancer Progression in Mice
• Metabolomic Targeting of Heterogeneous Breast Cancer for Personalized Therapy Development
• Ruxolitinib for the Prevention of Breast Cancer
• Fasting-Mimicking Diet Induces Breast Cancer Regression Through Enhanced Effectiveness of Hormone Therapy
• Characterization of Clustered Circulating Tumor Cells to Eliminate Breast Cancer Metastasis
• New Diagnostic and Therapeutic Approaches to Eradicating Recurrent Breast Cancer
• De-Escalating Treatment in HER2+ Breast Cancer: Establishing Effective and Less Toxic Therapy Based on Predictive Biomarkers
• Podcast Discusses the DoD Breast Cancer Research Program and Metastatic Breast Cancer Research
• Lab-on-Chip (LOC) Platform for Assessment of Extracellular Matrix (ECM) Stiffness
• Targeting miR551b to Prevent Tumor Formation and Metastasis of Triple-Negative Breast Cancer (TNBC)
• Death Effector Domain-Containing Protein (DEDD) Vulnerability to Cell Cycle Inhibition in Triple-Negative Breast Cancer (TNBC)
• Enhancing the Cytotoxicity of T-DM1 to Treat HER2+ Breast Cancer

Congressionally Directed Medical Research Programs:

• CDMRP-Funded Research Supports Suicide Prevention and Total Force Readiness
• CDMRP Advances AI-Based Metastatic Cancer Detection Through VA Partnerships
• CDMRP Accelerates Advancements in Cancer Screening for Warfighters, Veterans and the Nation
• CDMRP Receives $650M in Congressional Funds to Address Diseases, Conditions, Injuries Impacting Warfighters, Veterans, Americans

Combat Readiness-Medical:

• CDMRP-Funded Research Developed a Portable Exposure Biomarker Device for Lead and Other Heavy Metal Exposures
• Revolutionary Antiviral Nasal Drug to Combat Respiratory Illnesses
• A Nanotechnology-Enabled Biosynthetic Whole-Blood Surrogate for Hemostatic Resuscitation
• On-Demand Warming of Blood Products Using Non-Electric Fluid Warmers

Chronic Pain Management:

• CDMRP FUNDED RESEARCH ON FUNCTIONAL RESTORATION PROGRAMS FOR CHRONIC PAIN

Defense Medical Research and Development:

• Creating Clinical Solutions from Basic Research: A CDMRP Bone Story
• THE PAP SMEAR CHALLENGE: COMPARING CLINICAL PERFORMANCE OF A NOVEL "MOLECULAR PAP” BASED ON NEXT-GENERATION SEQUENCING TO TRADITIONAL CERVICAL CANCER SCREENING

Duchenne Muscular Dystrophy

• Toward a Safer and Better Gene Therapy for Duchenne Muscular Dystrophy
• New Potential Antibody Treatment for Duchenne Muscular Dystrophy
• Steps Forward in Treating Duchenne Muscular Dystrophy with Gene Repair Therapy

Epilepsy

• TGF-beta Signaling in Post-Traumatic Epileptogenesis: Novel Mechanisms and Therapeutic Target
• Re-Imagining Epilepsy Treatments - A Cocktail of Novel Small Molecules Shows Promise for Blocking Post-Traumatic Epilepsy
• Large Animal Models of TBI May Reveal the Mechanisms Behind Post-Traumatic Epilepsy
• The Epidemiology of Epilepsy and Traumatic Brain Injury: Severity, Mechanism, and Outcomes
• Hope for Repurposing an Anti-Diabetic Drug as a Potential Therapy in Pediatric TBI

Gulf War Illness:

• Gulf War Veterans' Perspectives Brought to Light in Educational Materials
• Boston University Tackles Gulf War Illness Through Collaboration and Community Resources
• Life Sciences Special Issue Focuses on Gulf War Illness Research
• The Unwavering Mission of the GWIRP Thirty Years after the Persian Gulf War
• Misconceptions about GWI and the Impact of Provider Attitudes: Assessing and Addressing Problems
• CNS autoantibodies lead to a differential diagnostic test for Gulf War Illness
• Joint VA/DoD Gulf War Illness State of the Science Conference Draws Hundreds of Researchers and Veterans
• Gulf War Illness State of the Science Conference

Hearing Restoration:

• Restoring Hearing Loss with Drug-Like Cocktails – A Preliminary Investigation
• HRRP Hosts Inaugural Meeting of Hearing Research Funders Network
• HRRP-funded investigators develop miniature imaging probe to visualize cellular pathology in the inner ear

Joint Warfighter Medical:

• Revolutionizing Oxygen Therapy for Trauma Patients, the SAVE-O2 Trial is a Leap Forward in Healthcare
• Sweaty Issues: Seeking to Reduce Residual Limb Perspiration to Improve the Quality of Life of Amputees
• NuCress^TM Bone Scaffolding Solution for Healing Bone Trauma on the Battlefield and Beyond
• Creating Clinical Solutions from Basic Research: A CDMRP Bone Story
• Enhancing Healthcare Through Interoperability
• A New Product for the Treatment of Post-Traumatic Osteoarthritis
• Development of BIO 301 to Prevent Acute Radiation Syndrome and Mitigate the Delayed Effects of Acute Radiation Exposure

Kidney Cancer:

• Advancing Therapeutics, Diagnostics, and Biomarker Discovery Video - Text Version
• Exploration of Iron Dependent Cell Death (Ferroptosis): A Novel Treatment Option for Patients with Clear Cell Kidney Cancer
• A Novel Mechanism of Pathogenesis for Renal Medullary Carcinoma
• The Academy of Kidney Cancer Investigators - Getting to Know Class 1 and 2
• Therapeutic Targeting of HHLA2/KIR3DL3 Axis as a Novel Immune Checkpoint Pathway in Renal Cancer
• Stromal β-catenin Activation Contributes to Abnormal Kidney Formation in Mice that Mimics Human Wilms Tumor
• Metabolic Reprogramming of Clear Cell Renal Cell Carcinoma Mediated by Tobacco Smoke
• Profilin 1 Promotes Aggressiveness of ccRCC and Provides a Potential New Therapeutic Target
• Harnessing Predictive Markers of Response to Antiangiogenic Therapy: Two Approaches to Optimizing Treatment for Metastatic Renal Carcinoma

Lung Cancer:

• THE CDMRP FUNDS RESEARCH TO ENHANCE TREATMENT AND UNDERSTANDING OF BRAIN METASTASES IN LUNG CANCER
• CAR T-cell Therapy for Lung Cancer – Incorporation of Self-Amplification and Safety Mechanisms
• Innovative Drug Combinations to Improve Immunotherapy for the Treatment of Non-Small Cell Lung Cancer
• Uncovering the Molecular Drivers of Tuft Cells Provides Insight into Potential Vulnerability in a Variant of Small Cell Lung Cancer
• A New Generation of Researchers: The Lung Cancer Research Program Supports the Development of Early-Career Investigators
• The Lung Cancer Research Program Supports Six Early-Career Investigators with Fiscal Year 2020 (FY20) Awards
• Rationalizing New Therapeutic Options for Small Cell Lung Cancer Patients Through a Deeper Understanding of Disease Heterogeneity
• Exploring Modulators of TKI Therapy to Inform Better Patient Treatment for Lung Cancer
• Peripheral Blood T-Cell Dynamic Biomarkers to Identify Responders and Non-Responders in Immune Checkpoint-Based Therapy for Lung Cancer
• LCRP Awardee Receives 2021 Wachtel Cancer Research Award
• Investigating Dysbiosis of the Lung as a Biomarker for Early Lung Cancer Detection
• The Generation of Pulmonary Neuroendocrine Cells and SCLC-like Tumors from Human Embryonic Stem Cells
• Lung Cancer Research Program's Career Development Award Expands the Talent Pool in the Field of Lung Cancer
• Targeted Inhibition of Mutant KRAS Oncogene Signaling by RAS Mimetics as a Therapeutic Approach for Lung Cancer
• Predicting Response to Immune Checkpoint Inhibition in Non-Small Cell Lung Cancer
• MEK Inhibition Modulates TNFα Response in Lung Cancer to Enhance Therapeutic Activity

Lupus

• Aim2 Couples with Ube2i for Repression of Interferon Signatures in Systemic Lupus Erythematosus
• Effects of ITGAM Genetic Variation on Mac-1-Mediated Functions of B-Cells
• Multi-Ancestral Genomic Approach to SLE-Precision Medicine
• The LRP Presents the Fiscal Year 2021 Transformative Vision Award Recipient
• The LRP Presents the Fiscal Year 2021 Impact Award Recipients
• The LRP Presents the Fiscal Year 2021 Idea Award Recipients
• An Individualized Approach to Cutaneous Lupus Erythematosus Response Therapy
• Developing Antigen-Specific Therapies for Systemic Lupus Erythematosus
• Clarifying Mechanisms of Treg Function as a Basis for SLE Therapy
• Correlation of Atmospheric Fine Particulate Pollution with Lupus Flare Activity
• Targeting IRF5 Hyperactivation in Lupus as a Driver of Disease Risk and Pathogenesis
• Therapeutic Targeting of Senescent Cells in Lupus
• Systemic Lupus: Improving the Rationale for Treatment Choices in a Heterogeneous Disease
• Utility of a Functioning Report for Lupus Patients and Their Providers

Melanoma:

• CDMRP Funds Collaborative Research on Melanoma, a Skin Cancer Disproportionately Affecting Service Members and Veterans
• The Melanoma Research Program Funds Second Cohort for the Melanoma Academy
• Beyond Sunscreen: Redefining Melanoma Prevention
• Introducing the Melanoma Academy
• The Melanoma Research Program’s Renewed Focus on Rare Melanomas and a New Funding Opportunity
• Oncoprotein “RLIP” as a Novel Therapeutic Target for Melanoma Prevention and Treatment
• Fiscal Year 2021 Melanoma Research Program Academy: An Opportunity for Leadership
• Breaking the Habit: Melanoma Cells Dependence on BRAF+MEK Inhibitors
• Improving Therapy for Melanoma Brain Metastases
• Identification of the HDAC Inhibitor Quisinostat as a Possible Therapeutic for Uveal Melanoma
• Exploring Novel Ideas in Melanoma Research
• FY20 Melanoma Research Program: Filling the Gaps in Research for a Better Future
• Siah2: A Potential Biomarker to Predict Immunotherapy Treatment Outcomes in Melanoma Patients
• Role of the Inhibitory Receptor TIGIT in the Regulation of CD4+ Tregs in Patients with Advanced Melanoma

Military Burn:

• Portable Nanoparticle Anesthetic Dressing for Burn Wounds
• Vitamin C:  An Inexpensive and Readily Available Potential Treatment for Severe Burn Patients
• Novel Peptide Drugs to Improve Burn Care Outcomes
• Enzymatic Debridement for Prolonged Field Care of Military Burn Wounds
• Pirfenidone-Containing Burn Wound Patch to Reduce Scarring
• Revised Goniometry for Improved Diagnosis and Physical Therapy for Burn Patients
• Omega-3 Fish Skin for Burn Wound Coverage and Advanced Healing

Multiple Sclerosis:

• CDMRP Funds Research to Support Service Members and Veterans with Multiple Sclerosis
• Glucagon-Like Peptide-1 Receptor Agonist as New Therapeutics for Multiple Sclerosis
• Bioengineered Particles to Promote Regulatory T Cells and Modulate the Immune System in Transplantation and Multiple Sclerosis
• Fitness Trackers and Smartphones Used to Predict Behavior Changes in People with Multiple Sclerosis During the COVID-19 Stay-at-Home Mandate
• Physical Telerehabilitation Program for Multiple Sclerosis Patients Improves Patients’ Quality of Life
• Reduced Disease Severity Following Novel Angiotensin 1-7 Treatment in MS Mouse Model
• Imaging Measures Reflect Cognitive Changes Over Time in Multiple Sclerosis Patients
• Exercise Training, Metabolic Changes, and Symptoms in People with MS
• Exploring Remyelination in MS: Myelin, Metformin, and Mitochondria
• Acceleration of Oligodendrocyte Maturation and Functional Remyelination in an MS Model Following Flavonoid Treatment
• The Role of Protein Deimination in Restoring Visual Function in MS Patients
• Differential Association of Age and Serum Neurofilament Light Chain in MS Patients
• Online Toolkit to Assist with Self-Management of MS Symptoms

Neurofibromatosis:

• New Investigator Award Recipients Bring New Ideas to the Neurofibromatosis Research Program for Fiscal Year 2022
• Sleep Disorders Among Children with Neurofibromatosis Type 1 (NF1)
• Improving Hearing in NF2 Patients Who Use the Auditory Brainstem Implant (ABI)
• Development of Therapeutic Strategies for NF1-Associated Optic Pathway Glioma
• NFRP Supports Multi-Institutional Synergistic Idea Award to Investigate Inflammation During NF-Related Optic Tumor Formation
• NFRP Funds First Research OTA to Support Neurofibromatosis Clinical Trials
• Neurofibromatosis Research Program (NFRP) Research Resources
• Genetic Risk Factors of Schwannoma Tumors
• Pharmacological Alk Inhibition Impacts Behavior and Cognition in Adult NF1 Mutant Mice
• Nf1 Mutation Drives Neuronal-Activity-Dependent Initiation of Optic Glioma
• New Investigator Award Recipients Bring New Ideas to the Neurofibromatosis Research Program for Fiscal Year 2020
• Cabozantinib for Neurofibromatosis Type 1-Related Plexiform Neurofibromas: A Phase 2 Trial
• Everolimus Therapy for NF1-Optic Gliomas in Children: A Clinical Trial
• The Pain of Neurofibromatosis
• The NFRP Supports the Future of NF Research with Several New Investigator Awards
• The NFRP Joins Efforts to Promote Open Science in NF Research
• Clinical Trials Address Quality of Life for Persons with Neurofibromatosis (NF1, NF2, and Schwannomatosis) with Resiliency Training Delivered via Live Video
• Study Finds That Bevacizumab Treatment for NF2-Related Vestibular Schwannomas Increases Reported Quality of Life in Adults and Children

Neurotoxin Exposure Treatment Parkinson's:

• The NETP Presents the Fiscal Year 2020 Early-Investigator Research Award Recipients
• Investigating the Gene-Environment Interactions Related to Parkinson's Disease Susceptibility
• The NETP Presents the Fiscal Year 2019 Early-Investigator Research Award Recipients
• Reducing Tau as a Therapeutic Strategy for Improving Cognitive Dysfunction in Parkinson's Disease
• Identifying an Additional Risk for Sporadic Parkinson's Disease in the Gut Microbiome

Orthotics and Prosthetics Outcomes:

• Improved Daily Comfort and Mobility for Lower-Limb Amputees Using Novel Release-Relock System
• Hip Muscle Quality and Osseointegration Outcomes
• Sweaty Issues: Seeking to Reduce Residual Limb Perspiration to Improve the Quality of Life of Amputees
• Enhanced Autodiagnostic Adaptive Trainer for Myoelectric Prosthesis Users (eADAPT-MP)
• The Narrow Beam Walking Test: An Improved Clinical Balance Test for Assessing Fall Risk in Unilateral Lower Limb Prosthesis Users
• Women's Specific Footwear with Prosthetic Feet

Ovarian Cancer:

• CDMRP-FUNDED RESEARCH SEEKS TO UNDERSTAND THE CONNECTION BETWEEN PSYCHOLOGICAL DISTRESS AND OVARIAN CANCER
• Falloposcope: A Minimally Invasive Tool for Early Ovarian Cancer Detection
• Leukemia Inhibitory Factor and Interleukin-6: Functioning in Parallel to Promote Ovarian Cancer Growth
• Exploiting the Immunometabolome to Enhance Antitumor Immunity in Ovarian Cancer
• Developing Therapeutics in Rare Subtypes of Ovarian Cancer
• Mentorship Is a Key Component for a Successful Ovarian Cancer Research Team
• Nanoparticles for Effective and Targeted Ovarian Cancer Treatment
• A microRNA Promotes Oncogenic Transformation Leading to Ovarian Cancer

Pancreatic Cancer:

• Early-Career Investigator Award Recipients Bring New Talent to the Pancreatic Cancer Research Program

Parkinson's:

• The PRP Presents the Fiscal Year 2022 Investigator-Initiated Research Award Recipients
• The PRP Presents the Fiscal Year 2022 Early Investigator Research Award Recipients
• The PRP Presents the Fiscal Year 2022 Synergistic Idea Award Recipients
• Exercise and Plasticity in PD: Functional and Structural Evidence in the Cortex and the Spinal Cord
• The Role of Astrocytes and Microglia in Exercise-induced Neuroplasticity in Parkinson's Disease
• Physical Therapy Incorporates Digital Health Technology and Behavioral Intervention to Improve Exercise Participation and Slow Down Parkinson's Progression
• Understanding the Role of Gene-Environment Interactions in the Degeneration of Human Dopaminergic Neurons in Parkinson's Disease
• Mechanisms of Specific Lipid-Induced Degeneration Causing Non-Motor Symptoms of Parkinson's Disease
• Effects of Exercise on Glymphatic Functioning and Neurobehavioral Correlates in Parkinson's Disease
• Synergistic Idea Award Highlights
• Investigator-Initiated Research Award Highlights
• Parkinson's Risk Estimation Using Digital Diagnosis Codes and Treatments
• Early Investigator Research Award Highlights
• Investigating Autonomic Nervous System Symptoms in Parkinson's Disease
• Exercise Impacts Parkinson's-Related Metabolic Pathways

Peer Reviewed Cancer:

• Peer Reviewed Cancer Research Program - 18 Cancer-Related Topics in FY24, Including Pediatric Brain Cancer
• New Behavioral Health Science Awards Aim to Improve Quality of Life in Pediatric, Adolescent, and Young Adult Cancer Survivors
• Novel Targets for the Treatment of Metastatic Colorectal Cancer
• IN FOCUS: Patient Well-Being and Survivorship in Cancer Care and Research
• Novel CAR-T Therapy Targeting BAFF-R Against B-Cell Lymphomas
• A Promising Nanotech Approach to Enhance Immunotherapy in Liver Cancer
• Thyroid Cancer Awareness Month: Innovations in Thyroid Cancer Research
• Combination Therapy Utilizing Prodrugs with Protoporphyrin IX Photodynamic Therapy
• Defining Microbial Ecosystems in Bladder Cancer Patients
• Fiscal Year 2020 Peer Reviewed Cancer Research Program Convergent Science Virtual Cancer Center
• Early Career Investigators Are Developing Strategies to Improve Outcomes in Head and Neck Cancers
• Boosting Listeria Hysteria: Prime Strategies Against Cancer
• Neutro-lizing Colorectal Cancer
• Defining Mechanisms of Resistance to Immunotherapy in Head and Neck Cancer
• Oncolytic Virotherapy: Boosting the Immune Response in Brain Cancer
• Attacking Cancer with Missiles
• Multifunctional Nanofiber for Convection-Enhanced Delivery of Theranostics to Diffuse Intrinsic Pontine Glioma
• Targeting Protein Degradation in Ewing Sarcoma
• FY20 PRCRP Awards Will Investigate Novel Ways to Treat Sarcomas that Disproportionately Affect the Pediatric, Adolescent, and Young Adult Populations
• Novel Therapeutic Strategies for Overcoming Treatment Resistance in Biliary Cancers
• Mantis Shrimp Inspired Near-Infrared Endoscopy for Colorectal Cancer Surgery
• Blood Cancer Breakthrough: Recently FDA-Approved XPOVIO ^® Research Was Initially Funded by DOD
• Imaging as Predictive Biomarker for Esophageal Cancer: Offering New Hope to a Forgotten Population of Cancer Patients
• In Focus: Cancer in Children, Adolescents, and Young Adults (CCAYA)
• In Focus: Military Health and Cancer
• A Powerful New Model for Accelerating Liver Cancer Research
• Research that Considers the Whole Patient
• Investigating the Link Between Potential Cancer-Causing Pollutants in the Environment and Testicular Cancer Risk in US Air Force Servicemen
• The Fiscal Year 2020 Peer Reviewed Cancer Research Program Virtual Cancer Center: An Opportunity for Leadership
• Role of the Inhibitory Receptor TIGIT in the Regulation of CD4+ Tregs in Patients with Advanced Melanoma
• Discovering New Drug Targets in Radiation-Induced Myeloproliferative Neoplasms

Peer Reviewed Medical:

• CDMRP Funds Research to Reduce Opioid Use in Veterans and Service Members with Chronic Pain
• Developing an Effective Treatment Option for Pancreatitis
• Promoting Regeneration and Healing During Bone Transport Using a Novel Implant Technology
• Strain-Programmable Bioadhesive Patch for Accelerated Healing of Diabetic Ulcer
• Developing a Portable Diagnostic Device for Rapid and Accessible Screening of Hepatitis B
• Improving Function Through Nonopioid Pain Relief in Service Members with Chronic Back Pain Following Trauma or Overuse Injury Using a Nonsurgical Therapy
• Group-Based Adaptations of Brief Cognitive Behavioral Therapy Effectively Mitigate Suicide Ideation in Military Personnel
• Clinical Development of a Novel Lung and Windpipe Sealant
• Development of DF-COV for the Treatment and Prevention of COVID-19 and Associated Immunopathologic Respiratory Complications
• Preclinical Advancement of Novel Mechanism-of-Action Therapeutics to Combat Type 2 Diabetes in US Veterans
• A Safer Alternative to Mechanical Ventilation in the Treatment of Acute Respiratory Distress Syndrome
• Prevention of Post-traumatic Osteoarthritis with CDK9 Inhibitors
• Development of an Innovative Combination Therapy Against Multidrug-Resistant Bacteria
• Web-Based Provider Training for Cognitive Behavioral Therapy of Insomnia (CBT I)
• Development of a Novel Cell-Based, Live Influenza Vaccine with Universal Attributes
• Development of (R)-ND-336 for the Treatment of Diabetic Foot Ulcers
• Growth-Adaptive Pediatric Heart Valves: Addressing a Critical Unmet Need for Infants and Young Children That Saves Lives and Reduces Surgeries
• Comparative Effectiveness of Acupuncture for Chronic Pain and Comorbid Conditions
• Mitigating the Effects of Acute and Delayed Radiation Exposure to Hematopoiesis and Blood Stem Cell Function Using the Prostaglandin E2 Signaling Cascade
• Novel Liver-Stage-Active Antimalarials
• A Novel Host-Protein Point of Need Platform for Differentiating Bacterial Versus Viral Infections: Transition from Prototype to Product
• Amicidin-α Surgical Gel for Prevention of Infections in Surgery and Trauma
• Novel RNAi Ovitraps to Protect Service Members from Mosquito-Borne Illnesses
• Development of Novel Pain Medications from Marine Sources to Replace Opioids
• Creating Clinical Solutions from Basic Research: A CDMRP Bone Story
• Investigating the Cellular and Molecular Mechanisms Associated with Worsened Outcomes in COVID-19 Patients with Chronic Lung Disease
• Development of BIO 301: An Encapsulated Nanogenistein Therapy

Peer Reviewed Orthopaedic:

• Enzyme-Responsive Hydrogels for Treatment of Post-Traumatic Osteoarthritis
• Effect of ALM Drug Therapy to Reduce Inflammation and Scar Formation After ACL Reconstruction Surgery: Targeting Earlier Return to Active Duty
• Improved Daily Comfort and Mobility for Lower-Limb Amputees Using Novel Release-Relock System
• Cognitive Function and ACL Rehabilitation
• Pre-Innervated Muscle Complexes: A New Avenue for Treatment of Volumetric Muscle Loss
• A Clinician-Friendly Algorithm to Create Low-Cost, Customizable Prosthetic Feet
• Early Data Suggests a Potential New Bioengineering Strategy for Treating Osteoarthritis
• Creating Clinical Solutions from Basic Research: A CDMRP Bone Story
• Development of Large Animal Models for Improved Regenerative Therapies in Bone Healing and Volumetric Muscle Loss Injury
• Seeking Multimodal Vaccines to Eradicate Biofilm-Associated Microorganisms Following Traumatic Musculoskeletal Injury
• New Information in Our Understanding of Osteoarthritis Onset

Prostate Cancer:

• CDMRP FUNDS MENTORED SCIENCE TO EXPAND CAPACITY FOR IMPACTFUL PROSTATE CANCER RESEARCH
• CDMRP Funds Impactful Prostate Cancer Research to Improve the Lives of Those Affected
• Therapeutic Targeting of Neuroendocrine Prostate Cancer
• B7-H3 (CD276) as a Therapeutic Target in Lethal Prostate Cancers
• An International Registry to Inform Treatment Choices for Patients with Advanced Prostate Cancer
• Unique Structural Characterization of Androgen Receptor - A Key Protein in Prostate Cancer
• PSMA-PET Imaging in Prostate Cancer: From Detection to Therapeutics
• Neuroendocrine Differentiation and Enzalutamide Resistance in Prostate Cancer
• Quality of Life among African American Prostate Cancer Survivors and Their Partners: A Multilevel Perspective
• Combining Nanotechnology and Radiation to Enhance Checkpoint Blockade Immunotherapy of Advanced Prostate Cancer
• The Impact of a Gene Expression Profile on Treatment Choice and Outcome among Minority Men Newly Diagnosed with Prostate Cancer
• Effects of CD24/RCC2/p53 Signaling on Prostate Cancer Metastasis
• Novel Tumor Suppressive Role of Phosphodiesterases in Prostate Cancer
• Alleviating Immunosuppression to Enhance CAR T-Cell Efficacy in Metastatic Prostate Cancer
• Identifying Genomic Drivers of Prostate Cancer Progression
• Investigating Racial Differences in the Financial Impact of Prostate Cancer
• Preserving Sexual Function in Men Undergoing Radiation Treatment for Prostate Cancer
• High dose testosterone causes DNA damage and suppresses prostate cancer growth
• Bipolar Androgen Therapy: Breaking Out of the Chrysalis of Chronic Androgen Deprivation Therapy in Men with Late-Stage Castrate-Resistant Prostate Cancer
• BET Bromodomain Degraders for the Treatment of Metastatic Prostate Cancer
• Using a novel genetically engineered mouse model to identify new drug targets for treatment-resistant metastatic prostate cancer

Rare Cancers:

• National Childhood Cancer Awareness Month: Advancing Research in More Than 13 Types of Childhood Cancers, Including Neuroblastoma
• Head and Neck Cancer Awareness Month: April 2023
• Cholangiocarcinoma Awareness: A Rare Cancer Too Dangerous for a "Watch-and-Wait” Approach
• NRTO: A Networking Platform for Rare Ovarian Cancer
• Rare Cancers Research Program Initiatives in Sarcoma Research
• Partnering with patients to create a rare soft tissue sarcoma target discovery platform as a community resource

Reconstructive Transplant Research:

• Ethical Factors Impacting Patients’ Decisions to Pursue VCA
• Bioengineered Particles to Promote Regulatory T Cells and Modulate the Immune System in Transplantation and Multiple Sclerosis
• Researching New Ways to Block Inflammation and Prevent Severe Tissue Damage Following Transplantation
• Regaining independence after the world's first successful combination face and double hand transplant
• Mapping the Inflammatory Response to Vascularized Composite Allotransplantation
• Transfer of Donor Lymph Nodes to Promote Graft Tolerance
• Engineered Microparticles for Promoting Transplant Tolerance: Taking a Page Out of Cancer's Playbook
• Increasing Organ Donor Authorization for Vascularized Composite Allotransplantation
• Improving and Quantifying Functional Hand Use in Hand Transplant Recipients and Amputees

Scleroderma:

• Preparing the Way for New Investigators While Fostering High-Impact Research: The Scleroderma Research Program’s Idea Development Award – New Investigator Collaboration Option

Spinal Cord Injury:

• Zeroing in on Neuropathic Pain in Spinal Cord Injury
• Melissa Nunn: Integrating as a Spinal Cord Injury Lived Experience Consultant within the Hiremath Research Team
• Update on TRACK-SCI: Toward Better Biomarkers and Data Accessibility for Spinal Cord Injury Research
• Stentrode: A SCIRP-Funded Device to Facilitate Independence After Paralysis
• TRACK-SCI: Leveraging Fundamental Clinical Discoveries to Guide Treatment and Improve Recovery after Spinal Cord Injury
• Acute Intermittent Hypoxia as a Multi-Functional Therapy for Spinal Cord Injuries
• Efficacy Study of a Fully Implanted Neuroprosthesis for Functional Benefit to Individuals with Tetraplegia
• Utilizing Nerve Transfers to Improve Hand Function Following Cervical Spinal Cord Injury
• Treatment of Sleep Apnea in Patients with Cervical Spinal Cord Injury

Tick-Borne Disease:

• Identifying How Spotted Fever Group Rickettsia Bacteria Invade and Promote Their Life Cycle in Host Cells
• Progress in Development of a Live Attenuated Vaccine for Powassan Virus
• Lyme Disease Awareness Month - Spotlight on Tick-Borne Disease Research Program Fiscal Year 2021 Lyme Disease Initiatives
• Wearable Devices for Controlled Release of Tick Repellents
• Lyme Disease Awareness Month - Spotlight on Tick-Borne Disease Research Program Fiscal Year 2020 Lyme Disease Initiatives
• A Pre-Exposure Immunoprophylaxis for the Prevention of Lyme Disease
• Lyme Disease Awareness Month - Spotlight on TBDRP FY19 Lyme Disease Initiatives
• Generation of a Vaccine Candidate to Protect Against Tick-Borne Ehrlichiosis
• Lyme Disease Awareness Month - Spotlight on TBDRP FY18 Lyme Disease Initiatives

Toxic Exposures:

• CDMRP Funds Research to Detect Military-Related Toxic Exposures and Diagnose Adverse Health Outcomes

Traumatic Brain Injury and Psychological Health:

• Treatment of Comorbid Sleep Disorders and PTSD
• Clinical Trial of Pregnenolone for the Reduction of Symptoms Associated with Traumatic Brain Injury
• Glecaprevir/Pibrentasvir for the Treatment of Posttraumatic Stress Disorder
• Novel Stem Cell Model Reveals How Neurons Respond to Stress in PTSD
• Prolonged Exposure Therapy for PTSD: 60-Minute Sessions as Effective as 90-Minute Sessions
• Clinical Trial of Sildenafil Citrate for Treatment of Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury
• Developing the Use of Intranasal Insulin for On-Field Treatment of Traumatic Brain Injury
• Validating a New Algorithm to Diagnose Traumatic Brain Injury in Far-Forward Settings

Tuberous Sclerosis Complex:

• CDMRP-Funded Tuberous Sclerosis Complex Research Addresses TSC-Associated Epilepsy
• The Role of Blood-Brain Barrier Dysfunction in Epilepsy in Tuberous Sclerosis Complex
• Beyond Rapamycin: A Search for Curative Therapies in TSC
• A New Mouse Model Sheds Light on the Origin of Epilepsy in Tuberous Sclerosis Complex
• A Timeline for Success: The FDA Approves New Topical Treatment for Facial Tumors in TSC
• Autophagy and the Neurocognitive Deficits in TSC
• Developing Novel mTORC1 Inhibitors to Treat TSC
• Genetic Analysis of TSC Tumors Identifies Novel Therapeutic Targets
• Neural Circuits Underlying Autism Relevant Behaviors in TSC
• TSC Remote Assessment and Intervention (TRAIN)
• Targeting Autophagy for the Treatment of TSC and LAM

Vision:

• CAPT Walter Steigleman, MD - Advancing Research for Military Vision Trauma (Watch on YouTube)
  Text Version
• MAJ Thomas Zampieri (USA Ret.), PhD, PA - Restoring Hope for Service Members with Eye Trauma (Watch on YouTube)
  Text Version
• Michael Steinmetz, PhD - Generating New Treatments for Warfighters and Their Families (Watch on YouTube)
  Text Version

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