Tuberous Sclerosis Complex
Research Highlights/News
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2025
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Anticipated Funding Opportunities for Fiscal Year 2025 (FY25)
January 7, 2025
2024
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Anticipated Funding Opportunities for Fiscal Year 2024 (FY24)
January 31, 2024
Research Highlights:
- CDMRP-Funded Tuberous Sclerosis Complex Research Addresses TSC-Associated Epilepsy
- The Role of Blood-Brain Barrier Dysfunction in Epilepsy in Tuberous Sclerosis Complex
News:
2023
Research Highlights:
2022
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Anticipated Funding Opportunities for Fiscal Year 2023 (FY23)
December 28, 2022
Research Highlights:
- A New Mouse Model Sheds Light on the Origin of Epilepsy in Tuberous Sclerosis Complex
- A Timeline for Success: The FDA Approves New Topical Treatment for Facial Tumors in TSC
- Autophagy and the Neurocognitive Deficits in TSC
- Developing Novel mTORC1 Inhibitors to Treat TSC
2021
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Anticipated Funding Opportunities for Fiscal Year 2022 (FY22)
December 16, 2021 - Department of Defense Tuberous Sclerosis Complex Research Program Anticipated Funding Opportunities for Fiscal Year 2021 (FY21)
January 7, 2021
Research Highlights:
News:
- Ninth Annual TSC Global Awareness Day Scheduled for May 15 (external link)
CISION - PR Newswire, May 17, 2021
2020
Research Highlights:
- Neural Circuits Underlying Autism Relevant Behaviors in TSC
- TSC Remote Assessment and Intervention (TRAIN)
- Targeting Autophagy for the Treatment of TSC and LAM
News:
- Tuberous Sclerosis Complex (TSC) Global Awareness Day Scheduled for May 15 (external link)
CISION PR Newswire, May 13, 2020
2019
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Anticipated Funding Opportunities for Fiscal Year 2020 (FY20)
December 17, 2019 - Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2019 (FY19) February 6, 2019
Research Highlights:
- Inhibition of Neuron Hyperexcitability In The TSC Brain May Provide A Therapeutic Option To Treat Seizures
- Causes of Epilepsy in TSC- Potential Therapeutic Targets
- Identifying Mechanisms Initiating LAM and Angiomyolipoma in Tuberous Sclerosis Complex
- Metabolic Imaging Biomarkers for TSC
- Repurposing FDA-Approved Drugs to Treat Tuberous Sclerosis Complex
- Gene Therapy, a New Approach to Treating TSC
News:
- TSC Global Awareness Day (external link)
CISION - PR Newswire, May 15, 2019
2018
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2018 (FY18) April 5, 2018
Research Highlights:
- Topical Rapamycin Therapy to Alleviate Cutaneous Manifestations of Tuberous Sclerosis Complex
- Modeling TSC and LAM Using Patient-Derived Induced Pluripotent Stem Cells
- A Novel Model Provides Insight into Tuberous Sclerosis Complex
- A Promising Early Intervention for TSC linked Autism in Infants
News:
- Rapamycin lotion reduces facial tumors caused by tuberous sclerosis (external link)
EurekAlert - Science News, May 29, 2018 - Lab-grown human cerebellar cells yield clues to autism (external link)
EurekAlert – Science News, February 22, 2018
2017
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2017 January 26, 2017
Research Highlights:
- Building Protein Network Models of Epilepsy to Find New Treatments in TSC
- Understanding the Mechanisms of Disease Leads to Potential New Treatments for TSC-related LAM
- Identifying the Roots of Myelin Dysfunction in the TSC Brain
News:
- TSC Global Awareness Day Scheduled for May 15 (external link)
PR Newswire, May 17, 2017
2016
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2016 January 13, 2016
Research Highlights:
- Inflammation and Epilepsy in TSC
- Targeting Amino Acid-mTORC1 Signaling for Treatment of TSC
- Loss of Tsc2 and Increased mTORC1 Signaling in Excitatory Neurons Lead to Complex Abnormalities
- TSC-FoxO Signaling Network in Kidney Cancer Development
2015
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2015 March 2, 2015
Research Highlights:
- The Effects of Protein Quality and Quantity in TSC Pathogenesis
- The TSCRP Recognizes November as Epilepsy Awareness Month
- Identification of a Novel Inhibitor that May Boost the Effect of mTOR Inhibitors
- Elucidating the Role of the mTOR Pathway in Tuberous Sclerosis
News:
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New drug squashes cancer's last-ditch efforts to survive (external link)
Salk Institute, July 28, 2015 -
2015 TSC Global Awareness Day News Release (external link)
Tuberous Sclerosis Alliance, May 1, 2015 -
Scientists identify first nutrient sensor in key growth-regulating metabolic pathway (external link)
Whitehead Institute, February 18, 2015
2014
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2014 January 31, 2014
Research Highlights:
- Defining the Balance between Protein Synthesis and Degradation by mTORC1 in Tuberous Sclerosis Complex
- Dysregulation of Cellular Metabolism: Novel Therapeutic Opportunities for TSC
- Defining Early Markers of Autism in Infants with TSC
- Targeting Estrogen-Induced COX-2 Activity in Lymphangioleiomyomatosis (LAM)
- A Mouse Model for Lymphangioleiomyomatosis (LAM)
- Understanding the Etiology of Tuberous Sclerosis Complex
2013
Press Releases:
- The second annual TSC Global Awareness Day May 14, 2013
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2013 April 15, 2013
Research Highlights:
- The TSCRP Recognizes November as Epilepsy Awareness Month
- PLK1 Inhibitors Show Promise as Potential Treatment for Tuberous Sclerosis Complex
- Loss of Tsc1 in Neurons in the Developing Thalamus Leads to Brain Abnormalities and Behavioral Symptoms
- Understanding Neural Development in tsc2-Deficient Zebrafish
News:
-
Advance in tuberous sclerosis brain science (external link)
Brown University, May 10, 2013
2012
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2012 February 8, 2012
Research Highlights:
- Using a Drosophila Model to Screen for Molecules to Reverse the Effects of Tsc Gene Mutations
- Role of Altered mGluR Activity in Cognitive Impairments in TSC: Implications for a Novel Method of Treatment
- LAMS Clinical Research Network
- Understanding the Etiology of Tuberous Sclerosis Complex
2010
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Anticipated Funding Opportunities for Fiscal Year 2011 December 20, 2010
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2010 January 7, 2010
Research Highlights:
- TSC-FoxO Signaling Network in Kidney Cancer Development
- The Role of Plk1 in Tuberous Sclerosis Complex
2009
Research Highlights:
- Regulation of Neuronal Differentiation in TSC
- Protein Synthesis-Dependent Synaptic Changes in Tuberous Sclerosis Complex
- Angiogenesis and Lymphangiogenesis as Chemotherapeutic Targets in Tuberous Sclerosis Complex
- TSC1 and TSC2 Variants Identified in Patients with Tuberous Sclerosis Complex
- The Rags Necessary to Mediate Amino Acid Signaling to mTORC1
2008
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2009 November 14, 2008
Research Highlights:
- Mechanism of TSC Regulation of Neuronal Differentiation
- The Importance of Rheb in Tuberous Sclerosis
2007
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2008 December 19, 2007
- Department of Defense Tuberous Sclerosis Complex Research Program 2007 Funding Update April 26, 2007
Research Highlights:
- Update to the Tuberous Sclerosis Complex (TSC) Natural History Database Studies
- New Software for Cell Image Analysis
News:
-
New Research Resources Initiative by the TSCRP
Published: January 3, 2007
2006
Press Releases:
- Tuberous Sclerosis Complex Research Program Funding Opportunities Pre-Announcement for Fiscal Year 2006 January 9, 2006
Research Highlights:
- TSC2 Regulates Cell Motility and Invasiveness
- TSC1 and TSC2 Regulate Neuronal Morphology and Function
- Tuberin Regulates mTOR Function in Response to Hypoxia
2005
Research Highlights:
- Elucidating the Functions of the TSC1 and TSC2 Genes
- Understanding the Causes of TSC-Related Epilepsy
2004
Press Releases:
- Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2005 September 22, 2004
2003
Press Releases:
- Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2004 December 22, 2003
- Department of Defense Tuberous Sclerosis Complex Research Program Announces Awards September 30, 2003
- FY02 Department of Defense Tuberous Sclerosis Complex Research Program Announces Awards September 12, 2003
Last updated Tuesday, January 7, 2025