GW080080

Ronald Bach

CRP-Associated Plasma Biomarkers of Inflammation

Johnson GJ, Leis LA, Slater BCS, et al. 2013. Elevated platelet count, CRP and thromboxane analog-induced platelet aggregation in subjects with Gulf War Veterans' Illnesses: Evidence of a chronic inflammatory state? Blood Coagul Fibrinolysis 24(7):736-741.

Johnson GJ, Slater BCS, Leis LA et al. 2016. Blood Biomarkers of Chronic Inflammation in Gulf War Illness. PLoS ONE 11(6): e0157855.doi:10.1371/journal.pone.0157855

ronald.bach@va.gov

GW080053

James Baraniuk

Cardiovascular indices and imaging based biomarkers post exercise challenge

Rayhan RU, Stevens BW, Raksit MP,et al. 2013. Exercise challenge in Gulf War Illness reveals two subgroups with altered brain structure and function. PLoS One 8(6):e63903

baraniuj@georgetown.edu

GW140064

James Baraniuk

Exercise – induced changes in cerebrospinal fluid miRNAs

James N. Baraniuk, Narayan Shivapurkar. 2017. Exercise-induced changes in cerebrospinal fluid miRNAs in Gulf War Illness, Chronic Fatigue Syndrome and sedentary control subjects. Scientific Reports 7: 15338 DOI:10.1038/s41598-017-15383-9. PMID: 29127316

baraniuj@georgetown.edu

GW080152

Nancy Klimas, Gordon Broderick

Altered immune pathway activity

Broderick G, Ben-Hamo R, Vashishtha S, et al. 2013. Altered immune pathway activity under exercise challenge in Gulf War Illness: An exploratory analysis. Brain, Behavior, and Immunity 28 (2013) 159 — 169

nklimas@nova.edu

gbroderick@nova.edu

GW110044

Jarred Younger

Immune factors to predict daily symptom severity in GWI

Parkitny L, Middleton S, Baker K, et al. 2015. Evidence for abnormal cytokine expression in Gulf War Illness:

A preliminary analysis of daily immune monitoring data. BMC immunology 16(1):57.

younger@uab.edu

GW120033

Lisa Pierce

miRNA and epigenetic biomarkers

Pierce LM, Kurata WE, Matsumoto KW, Clark ME, and Farmer DM. 2016. Long-term epigenetic alterations in a rat model of Gulf War Illness. Neurotoxicology 55:20-32.

lisa.m.pierce.civ@mail.mil

GW120071

Beatrice Golomb

Alterations in mitochondrial function (prolonged PCr-recovery time constant)

Koslik HJ, Hamilton G, and Golomb BA. 2014. Mitochondrial dysfunction in Gulf War illness revealed by 31Phosphorus Magnetic Resonance Spectroscopy: a case-control study. PLoS One 9(3):e92887.

bgolomb@ucsd.edu

GW140053

Apostolos Georgopoulos

inflammatory markers, C-reactive protein associated with symptom severity; erythrocyte sedimentation rate; autoimmune markers;

James LM, Engdahl BE, Johnson RA, Georgopoulos AP. Gulf War Illness and Inflammation: Association of symptom severity with C-reactive protein. J Neurol Neuromed. 2019; 4(2): 15-19. https://www.jneurology.com/articles/gulf-war-illness-and-inflammation-association-of-symptom-severity-with-creactive-protein.html.

omega@umn.edu

GW100076

GW130045

Ghania Ait-Ghezala Laila Abdullah

lysophospholipid species (lysophophatidylcholine and lysophosphatidylethanolamine); IL-1beta, IL-6, IFNgamma, CCR2, CCL2

Emmerich T, Zakirova Z, Klimas N, Sullivan K, Shetty AK, Evans JE, et al. (2017). Phospholipid profiling of plasma from GW veterans and rodent models to identify potential biomarkers of Gulf War Illness. PLoS ONE 12(4): e0176634.

gaitghezala@roskampinstitute.net

labdullah@roskampinstitute.net

GW140140

Kimberly Sullivan, Mohamed Abou Donia

serum autoantibodies

Abou-Donia MB, Lapadula ES, Krengel MH, Quinn E, LeClair J, Massaro J, Conboy LA, Kokkotou E, Abreu M, Klimas NG, Nguyen DD, Sullivan K. Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls. Brain Sci. 2020 Sep 5;10(9):610. doi: 10.3390/brainsci10090610. PMID: 32899468; PMCID: PMC7563126.

tty@bu.edu

donia@duke.edu

GW130100

Marco Loggia

TSPO marker of cerebral neuroinflammation using PET imaging

Alshelh Z, Albrecht DS, Loggia ML, et al. In-vivo imaging of neuroinflammation in veterans with Gulf War illness. Brain Behav Immun. 2020 Feb 4. pii: S0889-1591(19)31334-0. PMID: 32027960

marco@nmr.mgh.harvard.edu

GW093063

GW150066

Beatrice Golomb

increases in ceramides, sphingomyelins and phosphatidylcholine lipids in plasma of ill Gulf War veterans

Robert K. Naviaux, Beatrice A. Golomb, et al. Metabolic features of Gulf War illness. 2019. PLoS One.2019 Jul 26;14(7) https://doi.org/10.1371/journal.pone.0219531 PMID: 31348786

bgolomb@ucsd.edu

GW150076

Ashok Shetty

biomarkers of neuroinflammation (HMGB-1, TNFa, IL6) and complement activation (C3 and TccC5b-9) in the brain in an animal model

Madu LN, Attaluri S, Shetty AK, et al. Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood. Brain, Behavior, and Immunity 81 (2019) 430–443. PMID: 31255677

shetty@medicine.tamhsc.edu

GW150078

Kaundinya Gopinath

functional network connectivity

Gopinath KS, Sakoglu U, Crosson BA, et al. Exploring brain mechanisms underlying Gulf War Illness with group ICA based analysis of fMRI resting state networks. Neuroscience letters. 2019 May; 701: 136-141. https://doi.org/10.1016/j.neulet.2019.02.041 PMID:30825590

kgopina@emory.edu

GW160032

GW120037

Bang-Bon Koo / Kimberly Sullivan

neurite density imaging (NDI) + machine learning of structural changes in the brain

Guan Y, Cheng C-H, Chen W, Zhang Y, Koo S, Krengel M, Janulewicz P, Toomey R, Yang E, Bhadelia R, Steele L, Kim J-H, Sullivan K, Koo B-B. Neuroimaging Markers for Studying Gulf-War Illness: Single-Subject Level Analytical Method Based on Machine Learning. Brain Sciences. 2020; 10(11):884. https://doi.org/10.3390/brainsci10110884 PMID: 33233672

tty@bu.edu

bbkoo@bu.edu