Gulf War Illness (GWI) has affected a large number of Veterans of the 1990-1991 Persian Gulf War. GWI symptoms are characterized by chronic health problems, of unknown etiology. They resemble symptoms seen in various autoimmune disorders and are reflected in altered patterns of brain function. In this proposed research, we will assess comprehensively assess the association of GWI to autoimmune disorders using cutting-edge measures of brain structure and function, genetic analysis, and laboratory tests. In preliminary studies, we have discovered that GWI possesses a distinct functional brain pattern that is very close to that observed in a well-known autoimmune disorder, Sjogren's syndrome. Hence, the main goal of this proposal is to test the hypothesis that GWI is an autoimmune disorder. For that purpose, we will compare the results of brain, genetic, and laboratory tests in subjects with GWI to those to be obtained from subjects with known autoimmune disorders and determine the extent to which GWI reflects autoimmune abnormalities. Altogether, our study will improve knowledge of GWI pathophysiology and ultimately inform diagnosis and potential treatment of GWI, e.g., along lines currently in use for treating autoimmune disorders. It is expected that useful outcomes will be obtained by the end of the 3-year grant period. No risks in excess of those associated with routine medical care (e.g., blood draw, MRI scan) are expected. |
