Gulf War Illness
Research Resources Initiative by the GWIRP
- Biomarkers
- Multi-omics Datasets
- Animal Models
- Cohorts
In an effort to facilitate collaborations and speed GWI research, the GWIRP has compiled a list of various research resources produced from our funding. The list displays available resources and contact information. Please contact the PI(s) directly for information and requests.
| Award Number | PI | Model | References | Contact Information |
|
Mariana Morris |
Low dose sarin exposure in mice |
Oswal DP, Garrett TL, Morris M, et al. 2013. Low-dose sarin exposure produces long term changes in brain neurochemistry of mice. Neurochem Res 38(1):108-116. |
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|
Mohamed Abou Donia |
Rats dermally exposed to DEET and permthrin |
Abdel-Rahman, A.A., Shetty, A.K. and Abou-Donia, M.B (2001). Sub-chronic dermal application of N,N- diethyl-m-toluamide (DEET) and permethrin to adult rats, alone and in combination, causes diffused neuronal cell death and cytoskeletal abnormalities in the cerebral cortex and the hippocampus, and Purkinje neuron loss in cerebellum. Exp. Neurol. 172: 153-171. [Model established prior to GWIRP funding but reproduced and confirmed with the GWIRP award.] |
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Fiona Crawford and Ghania Ait-Ghezala |
Pyridostigmine Bromide and permethrin in mice |
Ojo JO, Abdullah L, Evans J, et al. 2014. Exposure to an organophosphate pesticide, individually or in combination with other Gulf War agents, impairs synaptic integrity and neuronal differentiation, and is accompanied by subtle microvascular injury in a mouse model of Gulf War agent exposure. Neuropathology 34(2):109-127. Zakirova Z, Tweed M, Crynen G, et al. 2015. Gulf war agent exposure causes impairment of long-term memory formation and neuropathological changes in a mouse model of gulf war illness. PLoS One. 10(3):e0119579. Zakirova Z, Crynen G, Hassan S, Abdullah L, Horne L, Mathura V, Crawford F, Ait-Ghezala G. A Chronic Longitudinal Characterization of Neurobehavioral and Neuropathological Cognitive Impairment in a Mouse Model of Gulf War Agent Exposure. Front Integr Neurosci. 2016 Jan 12;9:71. doi: 10.3389/fnint.2015.00071. eCollection 2015. PubMed PMID: 26793076; PubMed Central PMCID: PMC4709860. |
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Stephen Lasley and James O'Callaghan |
DFP treatment preceded by corticosterone in mice |
O'Callaghan JP, Kelly KA, Locker AR, Miller DB, Lasley SM. 2015. Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness. J Neurochem 133(5):708-721 |
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|
John Repine |
Inhalation methodology |
Repine JE, Wilson P, Elkins N,et al. 2016. Inhalation of two putative Gulf War toxins by mice. J Environ Sci Health B. 51(6):366-73. |
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|
Alvin Terry |
Repeated exposure to chlorpyrifos |
Hernandez CM, Beck WD, Naughton SX, et al. 2015. Repeated exposure to chlorpyrifos leads to prolonged impairments of axonal transport in the living rodent brain. Neurotoxicology 47C:17-26. |
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|
Brian Cooper |
DEET, Permethrin, chlorpyrifos, with or without pyridostigmine bromide (PB), with pain behaviors |
Nutter, T.J., Johnson, R.D. and Cooper, B.Y. A Delayed Chronic Pain Like Condition with Decreased Kv Channel Activity in a Rat Model of Gulf War Illness Pain Syndrome. NeuroToxicology 51 (2015) 67–79. |
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Last updated Thursday, May 26, 2022