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2024

Research Highlights:

• Identification of Actionable Networks Promoting Breast Cancer Progression and Brain Metastasis

News:

• Closing in on Triple-Negative Breast Cancer (external link)
  Cedars-Sinai, February 13, 2024
• Immune cells vs. metastasis: ‘It’s a numbers game’ (external link)
  Fred Hutch Cancer Center, January 23, 2024

2023

Press Releases:

• Defense Health Program Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2024 (FY24)
  December 4, 2023
• CDMRP-Funded Research Contributed to Test Included in the Defense Health Agency’s Pilot Program
  July 20, 2023

Research Highlights:

• Inhibition of Myeloid-Derived Suppressor Cell Biogenesis to Improve the Efficacy of Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer
• Epigenetic Factor CECR2 as a Potential Target in Breast Cancer Metastasis
• The CDMRP Remembers Dr. Susan Love
• Dual-Loading Antibody-Drug Conjugates for Combating Breast Cancer Tumor Heterogeneity and Drug Resistance
• Functional Mechanism and Targeting of Metadherin in Breast Cancer
• Targeting GM-CSF to Inhibit Development of Leptomeningeal Disease from Breast Cancer
• A Novel Tubulin Inhibitor to Overcome Taxane Resistance in Metastatic Breast Cancer

News:

• A potential strategy to control MAPK4-dependent cancer growth (external link)
  Baylor College of Medicine, August 29, 2023
• City of Hope scientists develop targeted chemotherapy able to kill all solid tumors in preclinical research (external link)
  City of Hope, August 25, 2023
• Multi-Generational Samples Allow Researchers to Search for Link Between Environmental Chemical Exposures During Pregnancy and Future Breast Cancer (external link)
  Public Health Institute, August 25, 2023
• Delivering on the promise of personalized breast cancer therapy (external link)
  Baylor College of Medicine, July 6, 2023
• Cleveland Clinic Announces Next Step in Preventive Breast Cancer Vaccine Study (external link)
  Cleveland Clinic, March 2, 2023

2022

Press Releases:

• Defense Health Program Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2023 (FY23)
  December 12, 2022
• Dr. Carolyn Bertozzi Awarded 2022 Nobel Prize in Chemistry
  October 7, 2022
• Defense Health Program Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2022 (FY22)
  October 7, 2022
• Defense Health Program Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2022 (FY22)
  May 26, 2022
• Defense Health Program Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2022 (FY22)
  November 3, 2021

Research Highlights:

• Tumor-Specific Fluorescence-Guided Surgery for Breast Cancer
• Overcoming HER2-Based Therapy Resistance in Breast Cancer Brain Metastases through CDK4/6 Inhibition
• Predicting Paclitaxel Sensitivity in Breast Cancer Patients
• Targeting Drug Resistance in Triple-Negative Breast Cancer
• Investigating Estrogen Receptor Mutations in Breast Cancer to Guide New Therapeutic Strategies
• Targeting Prolyl Peptidases in Triple-Negative Breast Cancer

News:

• New Treatment Strategy Could Boost Efficacy of Immunotherapy in Patients with Solid Tumors (external link)
  Roswell Park, December 13, 2022
• Leukemia Drug Shows Potential Against Breast Brain Metastasis (external link)
  Duke Cancer Institute, October 31, 2022
• UTSW researchers develop microbubble technology to enhance cancer immunotherapy (external link)
  EurekAlert!, June 17, 2022
• Astrocytes prevent tumor cell metastasis in the brain (external link)
  Fred Hutch, April 22, 2022
• A key to breast cancer metastasis lurks in the tiny cavities between cells (external link)
  Fred Hutch, April 22, 2022
• Yale Cancer Center study explores new path to treat advanced triple negative breast cancer (external link)
  Yale School of Medicine, March 24, 2022
• MAPK4 emerges as a novel therapeutic target for triple-negative breast cancer (external link)
  Baylor College of Medicine, February 1, 2022

2021

Press Releases:

• Defense Health Program Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2021 (FY21)
  April 8, 2021
• Defense Health Program Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2021 (FY21)
  October 19, 2020

Research Highlights:

• Identifying a Gene Panel to Predict Risk of Recurrence in Patients with Basal-Like Breast Cancer
• Targeting Senescence May Prevent Chemotherapy-Induced Bone Loss in Breast Cancer Patients
• Stromal Lysyl Hydroxylase 2, a Novel Biomarker for Breast Cancer Patient Prognosis
• Cluster of Differentiation 73 (CD73) Blockade Promotes Dendritic Cell Infiltration of Primary Tumors and Activation of Antitumor Immune Responses
• Mitochondria-Targeted Copper-Depleting Nanoparticle Inhibits Triple-Negative Breast Cancer Progression in Mice
• Metabolomic Targeting of Heterogeneous Breast Cancer for Personalized Therapy Development
• Ruxolitinib for the Prevention of Breast Cancer

News:

• New cancer therapy from Yibin Kang's lab holds potential to switch off major cancer types without side effects (external link)
  Princeton University, December 22, 2021
• Cleveland Clinic Launches First-of-its-Kind Preventive Breast Cancer Vaccine Study (external link)
  Cleveland Clinic, October 26, 2021
• Devi Awarded $1.6 Million for IBC Research Project (external link)
  Duke Cancer Institute, July 12, 2021
• Tumor Marker May Help Overcome Endocrine Treatment-Resistant Breast Cancer (external link)
  PR Newswire, July 1, 2021
• New discovery in breast cancer treatment (external link)
  EurekAlert!, February 23, 2021

2020

Press Releases:

• Defense Health Program Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2020 (FY20)
  April 13, 2020
• Defense Health Program Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2020 (FY20)
  November 7, 2019

Research Highlights:

• Fasting-Mimicking Diet Induces Breast Cancer Regression Through Enhanced Effectiveness of Hormone Therapy
• Characterization of Clustered Circulating Tumor Cells to Eliminate Breast Cancer Metastasis
• New Diagnostic and Therapeutic Approaches to Eradicating Recurrent Breast Cancer
• De-Escalating Treatment in HER2+ Breast Cancer: Establishing Effective and Less Toxic Therapy Based on Predictive Biomarkers
• Podcast Discusses the DoD Breast Cancer Research Program and Metastatic Breast Cancer Research
• Lab-on-Chip (LOC) Platform for Assessment of Extracellular Matrix (ECM) Stiffness
• Targeting miR551b to Prevent Tumor Formation and Metastasis of Triple-Negative Breast Cancer (TNBC)
• Death Effector Domain-Containing Protein (DEDD) Vulnerability to Cell Cycle Inhibition in Triple-Negative Breast Cancer (TNBC)
• Enhancing the Cytotoxicity of T-DM1 to Treat HER2+ Breast Cancer

News:

• Dr. Gayle Vaday, Program Manager of the Breast Cancer Research Program is featured on the podcast Our MBC Life (external link)
  Our MBC Life, September 25 , 2020
• UVA Discovers Key Process in Cancer Tumor Format (external link)
  UVA Today, September 21 , 2020
• Studies suggest a diet that mimics fasting could boost breast cancer therapy (external link)
  USC News, August 4 , 2020
• Cancerous tumors, surrounding cells illuminated by new imaging agent (external link)
  Washington University School of Medicine in St. Louis, March 13, 2020

2019

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2019 (FY19)
  January 8, 2019

Research Highlights:

• Connecting Blood and Intratumoral Treg Cell Activity in Predicting Future Relapse in Breast Cancer
• Blocking CXCR4 Reduces Tumor Fibrosis and Sensitizes Metastatic Breast Cancer to Immunotherapy
• Neutrophil Extracellular Traps Produced During Inflammation Awaken Dormant Cancer Cells
• Reprogramming the Pro-Tumorigenic Immune Microenvironment to Anti-Tumorigenic in Breast Cancer

News:

• Balance of “Stop” and “Go” Signaling Could Be Key to Cancer Immunotherapy Response (external link)
  Penn Medicine News, August 23, 2019
• So You Want to Serve on a Scientific Review Panel? (external link)
  Cancer Today, July 24, 2019
• A new approach to targeting tumors and tracking their spread (external link)
  MIT News, July 16, 2019
• Blood Test May Predict Risk of Recurrence for Breast Cancer Patients (external link)
  City of Hope, July 16, 2019
• Bacteria Engineered as Trojan Horse for Cancer Immunotherapy (external link)
  Columbia Engineering, July 11, 2019
• Tumor-selective angiotensin blockers may improve response to cancer immunotherapy (external link)
  Massachusetts General Hospital, May 2, 2019
• Vaccine for HER2 Breast Cancer Shows Early Promise (external link)
  Duke Cancer Institute, April 26, 2019
• Princeton scientists discover an interaction that helps cancer spread to bone (external link)
  Princeton University, April 24, 2019
• UW team finds key to common cancer pathway in discovery that could unlock new therapies (external link)
  University of Wisconsin–Madison, March 22, 2019
• Blocking pro-fibrosis pathway may improve immunotherapy of metastatic breast cancer (external link)
  Massachusetts General Hospital, February 4, 2019

Video Highlights:

• Era of Hope Scholars – Making Breakthroughs in Preventing Metastasis
• 2019 BCRP Landscape Video

2018

Press Releases:

• Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2018
  February 5, 2018

Research Highlights:

• RANKL/RANK Control BRCA1 Mutation-Driven Mammary Tumors
• Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy
• The Link Between Chromosomal Instability and Metastatic Progression in Triple-Negative Breast Cancer
• Imaging Agent, Flurodeoxyglucose (¹⁸F-FDG), Transforms Chemotherapeutics into Phototherapy for Precise Treatment of Metastatic Breast Cancer
• Atf3 in Non-Cancer Host Cells is Linked to Chemotherapy-Enhanced Metastasis in Breast Cancer
• Her2 and TrkB as Dual Therapy Targets for Her2+ Breast Cancer Brain Metastases
• Targeting the Cytoskeletal Physics of Circulating Breast Tumor Cells to Reduce Metastasis

News:

• New promise found in treating triple negative breast cancer (external link)
  Baylor College of Medicine, April 5, 2018
• Hidden Variation (external link)
  Harvard Medical School, March 30, 2018
• UPMC researchers solving treatment resistance in most common breast cancer (external link)
  EurekAlert – Science News, February 13, 2018
• Light-triggered nanoparticles show promise against metastatic cancer (external link)
  Washington University School of Medicine in St. Louis, January 30, 2018

2017

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2017
January 23, 2017

Research Highlights:

• Uncovering a New Pathway to Target and Treat Breast Cancer Metastasis
• The Multifunctional Transcription Factor, TRIM25, Drives Breast Cancer Metastasis
• RON kinase: A Target for Treatment of Cancer-Induced Bone Destruction and Osteoporosis
• CDK4/6 Inhibition Triggers Antitumor Immunity
• The Flare Behind Tumor Imaging to Rapidly Measure Breast Cancer Response to Therapy
• Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis
• Detection of HER2-Positive Metastases in Patients with HER2-Negative Primary Breast Cancer
• Breast Cancer Geneticist Awarded 2017 Breakthrough Prize
• Prediction of Metastasis Using Second Harmonic Generation

News:

• A New Weapon Against Bone Metastasis (external link)
  Princeton University, December 26, 2017
• Wearable Windows into Breast Tumors (external link)
  Boston University Today, May 4, 2017
• Mount Sinai study: How primary tumor cells are preset for dormancy and evade chemo after spread (external link)
Mount Sinai, February 3, 2017
• Huntsman Cancer Institute Scientists Identify Bone Degradation Process in Metastatic Breast Cancer (external link)
Huntsman Cancer Institute, February 3, 2017

2016

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2016 (Round 2)
June 30, 2016

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2016
January 15, 2016

Research Highlights:

• New Approach to Cancer Prevention in BRCA1 Mutation-positive Women
• RB1 Deficiency in Triple-Negative Breast Cancer Induces Mitochondrial Protein Translation
• Targeting the Tumor Microenvironment to Terminate Drug-Resistant Breast Cancer
• The Use of Polycationic Uptake Peptides for Fluorescence-Guided Surgery
• Uncovering the Epigenetic Origins of Basal-like Breast Cancer
• Amplification of JAK2 in Breast Cancer: A Molecular Lesion that Can Be Exploited Now
• Hazardous Air Pollutants and Breast Cancer: An Unexplored Area of Risk
• Breast Cancer Breakthrough: An Injectable Nanoparticle Generator Enhances Delivery of Cancer Therapeutics
• Regional Oncolytic Poliovirus Immunotherapy for Breast Cancer
• New Approaches to Eradicate Aggressive Breast Cancers
• Defining the Role of Nanoscale Membrane Bridges in Metastatic Breast Cancer

News:

• Biomarker could help guide cancer therapy, avoid drug resistance (external link)
  MIT News Office, December 14, 2016
• First Injectable Nanoparticle Generator Could Radically Transform Metastatic Breast Cancer Treatment (external link)
  Houston Methodist, March 15, 2016
• Triple-Negative Breast Cancers Depend on Fat as Fuel, Research Shows (external link)
  University of California San Francisco, March 10, 2016

Video Highlights:

• Amy Bonoff - In Tribute

Top of Page

2015

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2015
February 18, 2015

Research Highlights:

• Novel Targets for Aggressive Estrogen Receptor Positive Breast Cancer
• Gestational Exposure as an Epigenetic Modifier of Breast Cancer Risk
• Regulation of Breast Cancer Stem Cells by Tissue Rigidity
• Mechanisms Promoting the Colonization of Breast Cancer Metastases in Bone
• Modulating Immune Response to Improve Therapy for Breast Cancer
• Pasireotide, a Promising Alternative for Breast Cancer Chemoprevention Treatment

News:

• Wistar Receives $1.1M Award to Create Breast Cancer Consortium (external link)
  Genome Web, March 23, 2015

Top of Page

2014

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2014
March 3, 2014

Research Highlights:

• Vascular-Targeting Anti-Angiogenic Therapy of Human Breast Cancer
• Understanding the Molecular Mechanisms of Anti-Estrogen Resistance
• Immunology, Systems Biology, and Immunotherapy of Breast Cancer
• STAT5 as a Molecular Target for Breast Cancer Prevention
• Dissecting the Role of p63-Mediated Cell Adhesion in Collective Breast Cancer Invasion
• Novel Methylated Biomarkers and a Robust Assay to Detect Circulating Tumor DNA in Metastatic Breast Cancer
• HER-2/neu (E75) Vaccine to Prevent Breast Cancer Recurrence in High-Risk Patients
• Stimulation of Natural Killer Cells Enhances Trastuzumab Efficacy in Breast Cancer
• Mechanisms Behind Hypercholesterolemia-Associated Breast Cancer Risk and Progression

News:

• Breast cancer vaccine shows promise in small clinical trial (external link)
  Washington University in St. Louis, December 2, 2014
• Study shines new light on genetic alterations of aggressive breast cancer subtype (external link)
  Baylor College of Medicine, August 14, 2014
• How a Thick Sugar Coating" on cells May Drive Aggressive Cancers (external link)
  University of California San Francisco, July 21, 2014
• Novel noninvasive therapy prevents breast cancer formation in mice (external link)
  EurekAlert!, February 26, 2014
• OSU study: Osteoporosis drug may treat breast and liver cancers (external link)
  Oregon State University, February 21, 2014

Video Highlights:

• BCRP Landscape Video
• BCRP Investigator Highlights

Top of Page

2013

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2013
September 20, 2013

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2013
April 11, 2013

Research Highlights:

• Engineering an Intraoperative Imaging System to Improve Breast Cancer Surgery
• Genome-Wide Discovery of Inherited Structural Mutations in Breast Cancer Families
• Targeting Cadherin-11 in Basal-Like, Hormone-Refractory Breast Cancer
• Hybrid Nanotechnologies for Synergistic Therapies for Breast Cancer
• Targeting Androgen Receptor in Breast Cancer: Enzalutamide as a Novel Breast Cancer Therapeutic
• Enhancing Radiation Therapy with Ultrasound-Stimulated Microbubbles
• Structural and Functional Analyses of the Six1 Transcriptional Complex for Anti-Breast Cancer Drug Design
• Response, Resistance, and Metastasis of Locally Advanced Breast Cancer in a Multiethnic Cohort
• APOBEC3B: A Key Enzyme in Breast Cancer Mutations
• Palbociclib (PD-0332991), a "Breakthrough Therapy" for Breast Cancer
• Escape from Tumor Cell Dormancy
• Thermally Targeted Delivery of a c-Myc Inhibitory Peptide in Vivo Using Elastin-Like Polypeptide

News:

• How and where breast tumor cells become dormant and what causes them to become metastatic (external link)
  Lawrence Berkeley National Laboratory, June 5, 2013
• Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer (external link)
  Nature Genetics, April 17, 2013
• Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk (external link)
  PLOS Genetics, April 17, 2013
• Scripps Research Institute Scientists Find Promising New Approach to Preventing Progression of Breast Cancer (external link)
  The Scripps Research Institute, February 27, 2013
• In Breast Cancer Metastasis, Researchers Identify Possible Drug Target (external link)
  UCSF, February 20, 2013
• Breast Cancer and the Environment - Prioritizing Prevention (external link)
  NIEHS, February 13, 2013
• Vitamin D Holds Promise in Battling a Deadly Breast Cancer (external link)
  Saint Louis University, February 1, 2013

Top of Page

2012

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2012
September 11, 2012

• Cancer Survivors Mark 'Their' Day
May 31, 2012

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2012
January 23, 2012

• Stamp Sales Renewed to Fund Breast Cancer Research
January 11, 2012

Research Highlights:

• Overriding Systemic and Local Immunologic Checkpoints to Maximize Breast Cancer Immunotherapy

News:

• Researchers find potential cancer roadblock (external link)
  Michigan State University, August 17, 2012
• Researchers find driver of breast cancer stem cell metastasis (external link)
  University of Michigan Comprehensive Cancer Center, July 25, 2012
• World's fastest camera used to detect rogue cancer cells (external link)
  UCLA Newsroom, July 9, 2012
• Packaging therapeutic RNAs for targeted treatment of breast cancer (external link)
  Children's Hospital Boston, April 20, 2012
• Link between injectable contraceptive use and breast cancer risk (external link)
  Fred Hutchinson Cancer Research Center, April 17, 2012
• Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines (external link)
  Massachusetts General Hospital, April 17, 2012
• Functional Link Identified Between Two Causes of Breast Cancer Treatment Failure (external link)
  The Cancer Institute of New Jersey, April 12, 2012
• Salk scientists use an old theory to discover new targets in the fight against breast cancer (external link)
  Salk Institute, February 14, 2012
• Breast Cancer Cells Targeted, Then Burned, by Gold-Filled Silicon Wafer (external link)
  The Methodist Hospital System, January 25, 2012

Video Highlights:

• BCRP Investigator Highlights
• BCRP Consumer Stories

Top of Page

2011

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2011 (FY11)
July 6, 2011

Research Highlights:

• Phase II Study of Her2 Intracellular Domain Peptide-Based Vaccine Administered to Locally Advanced and Metastatic Her2+ Breast Cancer Patients Receiving Trastuzumab
• The Role of Progesterone and Estrogen in Breast Cancer Risk - Implications on Breast Cancer Therapy
• Breast Cancer Suppression by IDO Inhibitors
• Using SPECT-CT Imaging to Reduce Radiation Therapy-Induced Lymphedema in Breast Cancer Patients

News:

• Genetic rearrangements drive 5 to 7 percent of breast cancers (external link)
  University of Michigan Comprehensive Cancer Center, November 21, 2011
• Pathways point to BC vulnerability (external link)
  Whitehead Institute for Biomedical Research, June 9, 2011
• Study Suggests Breast Milk May Offer a More Accurate and Personalized Indicator of Breast Cancer Risk (external link)
  Published: April 4, 2011
• Berkeley Lab Researchers Illuminate Laminin's Role in Cancer Formation (external link)
  Published: March 4, 2011
• Scientists discover mechanism involved in breast cancer's spread to bone (external link)
  Published: February 3, 2011
• Purdue team creates 'engineered organ' model for breast cancer research (external link)
  Published: January 20, 2011
• Researcher works to identify "biomarkers" that could help boost cancer survival (external link)
  Published: January 11, 2011

Video Highlights:

• Plenary Sessions at the 2011 BCRP Era of Hope Conference
• Era of Hope Video
• Era of Hope Investigator Highlights

Top of Page

2010

Press Releases:

• Department of Defense Breast Cancer Research Program Anticipated Funding Opportunities for Fiscal Year 2011
December 9, 2010

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2010
September 22, 2010

Research Highlights:

• Successful Isolation of BRCA2 (breast cancer type 2 susceptibility protein) and Elucidation of Its Mechanistic Functions Underlying Breast Cancer Tumorigenesis
• Effects of Aerobic Training on Cardiovascular Function and Tumor Biology in Women Receiving Neoadjuvant Chemotherapy for Operable Breast Cancer
• Breast Cancer Stem Cells: Multidrug Resistance and Survival in the Bone Marrow Niche
• Characterization of DCIS Progenitor Cells Reveals New Therapeutic Target
• Computational Modeling of Gene Network States and Drug Responses
• A Novel TGFβ Mouse Model of Breast Cancer Metastasis
• Microenvironmental Regulation of Mammary Carcinogenesis
• Priming Breast Tumors for Better Chemotherapeutic Response
• Development and Evaluation of a Novel Radiation Therapy Technique for the Treatment of Vertebrae with Metastatic Lesions

News:

• Key Step Made in Understanding Origins of Familial Breast Cancer (external link)
  Published: August 23, 2010
• Improving a Cancer Drug Using Nanotechnology (external link)
  Published: June 25, 2010
• Study Reveals Mechanism Behind New Anti-Metastasis Agent (external link)
  Published: April 15, 2010
• Technological Leap for 3-D Cell Culture (external link)
  Published: March 15, 2010
• BCRP Synergistic Idea Award Leads to New Clinical Study (external link)
  Published: March 2, 2010
• Genes linked to breast cancer drug resistance (external link)
  Published: January 25, 2010
• Investigational Agent Reduces Tumor Resistance (external link)
  Published: January 6, 2010
• Targeting Breast Cancer Stem Cells (external link)
  Published: January 5, 2010
• Role of Self-Seeding in Tumor Progression (external link)
  Published: December 24, 2009

Top of Page

2009

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2010
December 23, 2009

• CDMRP-Funded Researcher Wins Nobel Prize
October 13, 2009

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2009
September 29, 2009

Research Highlights:

• Development of the BreastCancerTrials.org Website
• Characterization of Human Mammary Epithelial Stem Cells
• The Impact of Gestational and Postnatal Dietary Exposures on Metabolic Programming and Breast Cancer Risk
• The Influence of Neuronal Activity on Breast Cancer Metastasis
• Integrated Molecular Imaging and Therapy for Breast Cancer
• Fibrinogen-Mediated Mechanisms of Breast Cancer Metastasis
• Using MRI Technology to Improve Treatment Strategies for Breast Cancer
• Early Life Processes, Endocrine Mediators, and Number of Susceptible Cells in Relation to Breast Cancer Risk
• Converting Bcl-2 from a Protector to a Killer

News:

• Disparity Revealed in Standard of Care (external link)
  Published: December 14, 2009
• Study Reveals Benefits of Soy Foods (external link)
  Published: December 8, 2009
• Era of Hope Scholar Award (external link)
  Published: December 2, 2009
• Key Gene Identified in Inflammatory Breast Cancer (external link)
  Published: June 14, 2009
• How p53 Gene Mutations Link to Breast Cancer? (external link)
  Published: April 19, 2009
• Dr. Ferrari receives BC Innovator Award to Develop Treatment Nanocarriers (external link)
  Published: March 2, 2009
• Cell Microenvironments Hold Key to Future Therapies (external link)
  Published: February 24, 2009
• Breast Cancer Gene linked to Metastasis (external link)
  Published: January 5, 2009

Top of Page

2008

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2009
December 15, 2008

• Technical Difficulties with Grants.gov
November 7, 2008

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2008
September 29, 2008

Research Highlights:

• Targeting Detyrosinated Microtubule Protrusions to Reduce Breast Tumor Metastasis
• Combination Treatment of HER2/neu Expressing Breast Cancer Metastasis by Targeted alpha-Particle Radioimmunotherapy and Cancer Vacciner
• Nobel Prize in Chemistry Awarded to Breast Cancer Researcher
• Barriers to Breast Cancer Screening Among Latinas in the U.S.-Mexico Border Region
• Therapeutic Potential of Clostridium Perfringens Enterotoxin in Breast Cancer Brain Metastasis
• What a Concept! An Innovative Funding Mechanism for Breast Cancer Research
• Improving the Efficacy of Antiestrogen-Based Breast Cancer Therapies
• Breast Cancer Susceptibility Depends on the Genetic Ancestry of Latina Patients
• Tumor Stroma Predicts Clinical Outcome in Breast Cancer
• The Crystal Structure of a Potential Tumor Suppressor Bound to Its Target
• Genetic Counseling for Breast Cancer Susceptibility in African American Women
• Characterization and Restoration of Estrogen Sensitivity in Breast Cancer
• α6β4 Integrin Activation of NFκB-dependent Apoptosis Resistance in 3D Mammary Acini

News:

• Racial Disparities in Radiation Therapy Rates for Breast Cancer (external link)
  Published: September 4, 2008
• Fruit Fly Protein Acts as Decoy (external link)
  Published: Published: May 28, 2008
• Neuronal Regulators Offer Potential Targets for Cancer (external link)
  Published: March 19, 2008
• Noted BC Innovator, Dr. Judah Folkman, Dies at 74 (external link)
  Published: January 15, 2008

Video Highlights:

• Era of Hope Highlights

Top of Page

2007

Press Releases:

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2008
December 19, 2007

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2008
December 10, 2007

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2007
December 5, 2007

• Five CDMRP Funded Scientists Elected to Institute of Medicine
October 23, 2007

• Department of Defense Breast Cancer Research Program Funding Opportunities for Fiscal Year 2007
February 26, 2007

Research Highlights:

• New Predictors of Patient Survival after Neoadjuvant Chemotherapy
• Cytoskeletal Control of Mammary Epithelial Morphogenesis and Tumorigenesis
• Center of Excellence Highlights
• Legubicin, a Tumor-Activated Prodrug for Breast Cancer Therapy
• Nestin: A Selective Marker for Basal Epithelial Breast Tumors
• Understanding the Breast Cancer Metastatic Process in Bone

News:

• Discovery to Improve BC Radiation Therapy (external link)
  Published: November 1, 2007
• Genome Defines Landscape of Breast Cancers (external link)
  Published: October 11, 2007
• Breast Cancer Innovator Strives to Improve Screening (external link)
  Published: October 2, 2007
• New Approach Leads to Discovery of Gene Linked to Breast Cancer (external link)
  Published: June 14, 2007
• Hamilton College Researchers Discover New Molecules with the Potential to Treat Breast Cancer (external link)
  Published: May 4, 2007
• Fox Chase Researchers Identify Key Gene Marker of Breast Cancer (external link)
  Published: April 18, 2007
• Selective Marker for an Aggressive Breast Cancer Found (external link)
  Published: January 16, 2007

Top of Page

2006

Press Releases:

• Breast Cancer Research Program Announces Additional Funding Opportunities for Fiscal Year 2006
December 6, 2006

• Breast Cancer Research Program Announces Fiscal Year 2006 Innovator Award Funding Opportunity
August 21, 2006

• Breast Cancer Research Program Funding Opportunities Pre-Announcement for Fiscal Year 2006
January 9, 2006

Research Highlights:

• Metastasis: Human Breast Cancer to Bone
• S14 as a Therapeutic Target for Breast Cancer
• Chromosomal Instability (CIN) Signatures for Human Cancers
• ATM Variants are Breast Cancer Susceptibility Alleles
• VEGF¹²¹/rGel: Therapeutic agent targeting neovasculature of breast tumor
• Targeting Breast Cancer Vasculature with Homing Peptides
• Biomimetic Composite Scaffold for Breast Reconstruction Following Tumor Resection
• Evaluation of Hyperspectral Imaging as a Tool for Identifying Breast Cancer Tissue In-Situ

News:

• Genome Code Cracked for Breast and Colon Cancer (external link)
  Published: September 7, 2006
• DOD Awards $10.7 Million Center of Excellence Grant to Fox Chase Cancer Center's V. Craig Jordan (external link)
  Published: September 7, 2006
• Dartmouth Research Points to Protein S14 in Treating Breast Cancer (external link)
  Published: August 21, 2006
• Mammography Screenings for Breast Cancer Show Racial and Ethnic Disparities (external link)
  Published: April 17, 2006
• Breast Ducts: A New Site for Cancer Treatment? (external link)
  Published: January 25, 2006
• Cell Stress Protein Linked to Breast Cancer (external link)
  Published: January 4, 2006

Top of Page

2005

Press Releases:

• Department of Defense Breast Cancer Research Program Announces Concept Awards
December 6, 2005

• Light & Sound Join Forces To Improve Breast Cancer Imaging
June 9, 2005

• Dietary Measures And Exercise: New Twists On The Link To Prevention And Metastasis Of Breast Cancer
June 9, 2005

• Focusing On New Targets To Enhance Breast Cancer Treatment
June 9, 2005

• New Strategies Aim To Strengthen Mammography Accuracy
June 9, 2005

• Breast Cancer Research Program Funding Opportunities Pre-Announcement for Fiscal Year 2005
January 21, 2005

Research Highlights:

• MMP-3-Induced Epithelial-Mesenchymal Transition and Genomic Instability
• Chk1: The Doctor Jekyll and Mr. Hyde of the Cell Cycle
• Single Cell Protein Profiles for Improved Diagnosis and Treatment of Breast Cancer
• Preventing the Angiogenic Switch in Human Breast Cancer
• An Antibiotic That Kills Breast Cancer Cells
• The Wealth of the Rain Forest
• Identifying the Risk of Breast Cancer Recurrence in Patients Treated with Tamoxifen

News:

• Primose Oil Component Cuts Levels of Cancer Gene (external link)
  Published: November 2, 2005
• Breast Cancer Centers of Excellence Awards
  Published: November 1, 2005
• Curcumin halts spread of breast cancer in mice (external link)
  Published: October 14, 2005
• Illnesses Play a Role in Difference in Breast Cancer Survival Rates (external link)
  Published: October 13, 2005
• Penn Named a “Breast Cancer Center of Excellence (external link)
  Published: July 27, 2005
• Benign Breast Disease and the Risk of Breast Cancer (external link)
  Published: July 20, 2005
• Breast Cancer Research at Berkeley Lab (external link)
  Published: June 29, 2005
• Hamilton College Researchers Shields and Kirschner Receive Grant (external link)
  Published: June 27, 2005
• Arm swelling common among young breast cancer patients (external link)
  Published: June 11, 2005
• Era of Hope Meeting Highlights Breast Cancer Research (external link)
  Published: June 2005
• Exercise Helps Recovery from Chemotherapy for Breast Cancer (external link)
  Published: June 10, 2005
• DoD Funds 5 Breast Cancer Researchers at the University of Chicago (external link)
  Published: February 3, 2005
• Novel Theory of Breast Cancer Tumor Growth Receives Research Funding (external link)
  Published: January 12, 2005

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2004

Press Releases:

• Department of Defense Breast Cancer Research Program Announces Concept Awards
December 8, 2004

• Department of Defense Breast Cancer Research Program Announces Era of Hope Scholar Awards
December 8, 2004

• Breast Cancer Research Program Funding Opportunities for Fiscal Year 2004
January 21, 2004

Research Highlights:

• Early Life Events and the Risk of Breast Cancer
• Bryostatins: Potential breast cancer therapeutic agents from the sea?
• Making Sense Out of Too Much Noise: Information is Power in Breast Cancer Treatment
• Early Detection of Breast Cancer by Molecular Analysis of Ductal Lavage Fluid

News:

• Vitamin D May Help in Battle Against Breast Cancer.
  Published: February 29, 2004
  Research being conducted by JoEllen Welsh, a professor of biological sciences at Notre Dame, is offering
  intriguing clues about the role vitamin D might play in breast cancer treatment and prevention.
  http://newsinfo.nd.edu/news/6758-spotlight-vitamin-d-may-help-in-battle-against-breast-cancer

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2003

Press Releases:

• Department of Defense Breast Cancer Research Program Awards Summary for Fiscal Year 2003
December 10, 2003

• Department of Defense Breast Cancer Research Program Announces Concept Awards for Fiscal Year (FY) 03
December 2, 2003

• FY02 Breast Cancer Award Announcement
September 26, 2003

• FY02 Breast Cancer Award Announcement: BC Center of Excellence Awards
September 5, 2003

• Department of Defense Breast Cancer Research Program for Fiscal Year 2003
February 25, 2003

• Department of Defense Breast Cancer Research Program Changes in the Fiscal Year 2003
February 25, 2003

• Department of Defense Breast Cancer Research Program Announces Concept Awards
January 17, 2003

Research Highlights:

• Guilt by Association: The Complexity of Breast Cancer
• Tumor-Mediated Formation of Lymphatic Vessels: Building Roads Out
• Alternative Medicines Open New Doors in Traditional Breast Cancer Research: Targeted Therapy for Tumor Angiogenesis and Cancer

News:

• Georgetown University announces the $7M Breast Cancer Research Program, Center Excellence Award
  Published: July 7, 2003
  Washington, D.C. - The Lombardi Cancer Center at Georgetown University will establish a multi-institution
  Breast Cancer Center of Excellence to study the link between alcohol consumption and breast cancer.
  https://cdmrp.army.mil/pubs/pdf/030723BCShields.pdf
• Oubre, Michael "La Jolla Institute for Molecular Medicine Scientist Receives $505,983 Award from Department of Defense", Press Release of the La Jolla Institute for Molecular Medicine.
  Published: May 22, 2003
  SAN DIEGO - Carole L. Banka, Ph.D., an Associate Professor and Director of Women's Health Research at the La Jolla Institute for Molecular Medicine (LJIMM), has been selected to receive a Concept Award from the Department of Defense, Breast Cancer Research Program (BCRP), for her innovative proposal for studying the role of sex steroids in tumor metastasis.
  http://www.freshnews.com/news/45996/la-jolla-la-jolla-institute-molecular-medicine-scientist-receives-500000-award-dod
• Baker, Lois "Having more than two alcoholic drinks at a time increases younger women's breast-cancer risk by 80 percent", University at Buffalo Reporter
  Published: June 12, 2003
  Results from a case-control study on alcohol consumption and breast-cancer risk conducted by UB epidemiologists indicate that premenopausal women who usually have more than two drinks per occasion have an 80 percent greater risk of developing breast cancer than women who drink less on each occasion.
  http://www.buffalo.edu/reporter/vol34/vol34n29/articles/BreastCancer.html
• Boyd, Jade "Halas Wins Innovator Award in Fight Against Breast Cancer"
  Published: July 31, 2003
  The Department of Defense Breast Cancer Research Program has chosen Rice's Naomi Halas
  to receive the prestigious Innovator Award for ongoing research of novel ways to use nanotechnology to
  diagnose and treat breast cancer.
  http://www.media.rice.edu/media/NewsBot.asp?MODE=VIEW&ID=1675&SnID=579034492

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2002

Press Releases:

• Two New Strategies May Enhance Breast Cancer Treatment
September 28, 2002

• Novel Techniques For Predicting Risk Of Breast Cancer And Finding It Early
September 28, 2002

• Molecular Targets: Breaking The Chain Of Cancer Causation
September 28, 2002

• Natural Compounds From Plants And Animals May Prove Useful In Suppressing Mammary Tumors
September 27, 2002

• New Data May Alter Frequency And Surgical Procedure For Lymph Node Biopsies In Early-Stage Breast Cancer
September 26, 2002

• Innovator Award Recipients from the DOD Breast Cancer Research Program
April 22, 2002

• Department of Defense Breast Cancer Research Program for Fiscal Year 2002
February 22, 2002

Research Highlights:

• Advancing Breast Cancer Diagnosis through New Imaging Techniques
• Managing Cancer Pain through Gene Therapy
• Predictors of Follow-up after an Abnormal Mammogram
• Inhibition of Breast Cancer Cell Growth by Citrus Limonoids
• Particle-Mediated IL-12 Gene Transfer in Breast Cancer

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2001

Press Releases:

• Examples of HBCU/MI and Population-Specific Funded Research Projects
April 10, 2001

• Department of Defense Breast Cancer Research Program for Fiscal Year 2001
February 8, 2001

Research Highlights:

• Potential Anti-Cyclin D1 Therapy for Breast Cancer
• Sentinel Lymph Node Biopsy and Molecular Analysis in the Management of Breast Cancer
• Does Exercise Really Help during Chemotherapy?
• RNA Polymerase II in the Act of Transcription

News:

• Carter Mallet, Karen "Fox Chase Cancer Center Awarded Six Million Dollar Grant from Department of Defense: Establishes Nation's First Behavioral Research Center of Excellence for Breast Cancer", press release of the Fox Chase Cancer Center.
  Published: May 23, 2001
  The grant covers research in three areas and spans four years. The Behavioral Center of Excellence is the first program of its kind to comprehensively address unresolved issues relating to the impact of breast cancer on women and their families.
  http://www.fccc.edu/information/news/press-releases/2001/2001-04-25-DOD.html

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2000

Press Releases:

• Computer Technology Helps Radiologists Spot Overlooked Small Breast Cancers
July 20, 2000

• Minimally Invasive Approaches Characterize Innovative Techniques for Early Detection and Treatment in Breast Cancer
July 20, 2000

• Using the Body's Anticancer Defenses to Guide and Improve Breast Cancer Treatment
July 20, 2000

• Two Studies Elucidate "Quality of Life" Issues in Testing and Treatment for Breast Cancer
July 20, 2000

• Vaccine Studies Demonstrate Promise of Immunotherapy Both to Treat Breast Cancer and Prevent Recurrence
July 20, 2000

• New Data Clarify Treatment and Family Support Needs of Young Women with Breast Cancer
July 20, 2000

• FY00 Breast Cancer Research Program
March 10, 2000

• Breast Cancer Research Program Concept Award
February 17, 2000

News:

• Mahone, Sloan. "Spotlight on Funding: The Department of Defense Wants you." HABIT
  Published: March 16, 2000
  Recognizing the critical importance of social, behavioral, and lifestyle factors on breast cancer,
  the Department of Defense (DOD) has challenged the scientific community to focus creative efforts on founding cutting-edge behavioral research centers.
  https://cdmrp.army.mil/pubs/pdf/habit.pdf

1999

Press Releases:

• FY98 Breast Cancer Research Program Awards Summary
October 20, 1999

• Exercising for Life: Penn State Study Examines Whether Exercise Can Speed Women's Recovery Following Chemotherapy for Breast Cancer
June 12, 1999

• NCI & DOD Announce Pilot Program
March 30, 1999

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