DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS
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NEWS RELEASE

Released: December 19, 2007

Department of Defense Tuberous Sclerosis Complex Research Program Funding Opportunities for Fiscal Year 2008

The Fiscal Year 2008 (FY08) Defense Appropriations Act provides $4 million to the Department of Defense Tuberous Sclerosis Complex Research Program (TSCRP) to promote innovative research focused on lessening the impact of tuberous sclerosis complex. This program is administered by the US Army Medical Research and Materiel Command through the Office of the Congressionally Directed Medical Research Programs (CDMRP).

The mission of the TSCRP is to encourage innovative research aimed at understanding the pathogenesis of TSC and improving its diagnosis and treatment. Scientific ventures that represent underinvestigated avenues of research or novel applications of existing technologies are highly sought.

FY08 TSCRP program announcements for proposals in the following mechanisms are anticipated to be posted and available on Grants.gov between January and February, 2008.

Award Mechanism

Experience of Principal Investigator

Key Mechanism Elements

Dollars Available

Concept Award

All levels of experience

  • Fund exploration of untested, high-risk questions relevant to tuberous sclerosis complex (TSC) and/or the development of novel preclinical tools needed to advance TSC research
  • Projects involving human subjects or human biological substances must be exempt under 32 CFR 219.101(b)(4)
  • Preliminary data not required

  • A maximum of $75,000 in direct costs, for a 1-year performance period, plus indirect costs as appropriate
  • Anticipate 3-4 awards

Idea Development Award

Must be Independent investigators at the Assistant Professor level (or equivalent) or higher

  • Encourage innovative research directed toward understanding the pathogenesis of TSC and improving its diagnosis and treatment
  • Preliminary data required
  • Focus areas are clinical resources and translational research

  • A maximum of $450,000 in direct costs, for up to a 3-year performance period, plus indirect costs as appropriate.
  • Anticipate 2-3 awards

Clinical Research Award

Must be independent non-mentored investigators

  • Support TSC research projects performed by clinical researchers involved in the clinical care of individuals with TSC
  • The research should lead to a demonstrated improvement in clinical outcome or the development of a metric for clinical outcome
  • 10% to 25% guaranteed protected time of the PI is required
  • Preliminary data are required

  • A maximum of $300,000 in direct costs, for up to a 3-year performance period, plus indirect costs as appropriate
  • Anticipate 1-2 awards

Career Transition Award

Postdoctoral investigators within 2-3 years of completing their postdoctoral work

  • Support TSC researchers during the transition from postdoctoral training to an independent position
  • Funds the final 2 years of the postdoctoral position and the first 2 years of a faculty/independent position
  • Preliminary data are required

  • 4-year performance period
  • A maximum of $69,000 in direct costs per year for years 1-2 (postdoctoral position) plus indirect costs as appropriate
  • A maximum of $100,000 in direct costs per year for years 3-4 (faculty position) plus indirect costs as appropriate
  • Anticipate 1-2 awards

Information in this preannouncement is being provided to allow investigators time to plan and develop proposals. All proposals submitted must conform to the final program announcements, to be posted in Grants.gov at a later date. The number of awards anticipated is based on available funds, average cost of proposals and quality of proposals received. The TSCRP reserves the right to make awards in greater or lesser numbers than anticipated. Each program announcement will be available electronically for downloading from the Grants.gov website.

Requests for email notification of the program announcement release may be sent to Help@cdmrp.org. For more information about the TSCRP or other CDMRP-sponsored programs, please visit the CDMRP website.

A Letter of Intent (LOI) will be required and will be submitted through the CDMRP e-Receipt website. As of 2007, full proposals requesting funding from the CDMRP have been submitted through the Federal Government's single entry portal, Grants.gov, in compliance with Public Law 106-107. Individual program announcements and required forms will also be found on that website.

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