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The PRCRP has developed a strategy to address multiple issues in cancer research over the spectrum of different cancer topics considered for funding. These Overarching Challenges are critical gaps in cancer research, care, and/or patient outcomes that will advance mission readiness of U.S. military members affected by cancer and improve quality of life by decreasing the burden of cancer on Service Members, their families, Veterans, and the American public.

• Prevention
• Investigate primary, secondary, and tertiary prevention interventions/strategies to decrease cancer burden.
• Determine the risk factors, etiology, or mechanisms underlying cancer development to improve prevention interventions.
• Diagnostics/Prognostics
• Identify approaches to predict treatment resistance, recurrence, and the development of advanced disease.
• Distinguish unique features driving cancer occurrence across the spectrum of ages.
• Develop and improve minimally invasive methods for neoplasia detection, initiation, progression, and recurrence.
• Therapeutics
• Transform cancer treatment, especially for advanced, recurrent, and metastatic disease.
• Improve current therapies including systemic and local treatments.
• Evaluate disease progression and/or treatment response over time.
• Leverage the mechanisms of cancer development to improve treatment methods for all communities.
• Patient Well-Being and Survivorship
• Study methods to address survivorship issues, including quality of life, wellness, mental health, psychological impact of recurrence, reproductive/sexual health, and/or disability.
• Reduce short- and long-term treatment toxicities, including neurocognitive and physical effects.
• Investigate ways to bridge gaps between treatment and survivorship, including alternative medicine, nutrition and lifestyle factors, and supportive care.
• Understand and address the immediate and enduring burdens on caregivers, families, and communities.
• Disparity
• Improve prevention strategies, diagnosis, treatment, and outcomes for patients in underserved or under recognized populations.
• Study methods to improve accessibility to care and address survivorship.
• Advance health equity and reduce disparities in cancer care, including telehealth.
• Develop strategies to understand barriers to and improve communication amongst provider, patient, and care network.