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Tuberous Sclerosis Complex
Research Resources Initiative by the TSCRP


The TSCRP now offers a service on our website featuring a listing of newly available TSC research resources! Our goal is to facilitate and speed TSC research by publicizing new resources and aiding collaborations. The list displays available resources and PI contact information. Please contact the PIs directly for information and requests.

Award Number PI Product or Resource References Contact Information or Link
Yeast Models

TS043009

Tomohiro Matsumoto

S. pombe strains:

    (1)
  1. h- tsc2::ura4+ ura4-D18 leu1-32 cpp1-1 (YKK25)
  2. h- tsc1::ura4+ ura4-D18 leu1-32 cpp1-1 (YKK59)
  3. h-urs4-D18 leu1-32 cpp1-1 (YKK55)


    4. (2)
  4. h- rhb1-DA4 leu1-32 (M5-1e1)
  5. h- rhb1-DA4 (M5-2g3)
  6. h+/h-ade6-M210/ade6-M216 (M6-1)
  7. h+/h- rhb11/rhb1-DA4ade6-M210/ade6-M216 (M6-13 )
  8. h- rhb1-DA4 cpp1-1 (M7-1)
  9. h- rhb1-DA8 leu1-32 (M20-76)
  10. h- rhb1-DA8 (M21-13 )
  11. h- rhb1-DA8 cpp1-1 (M38-9)
  12. h+/h-rhb11/rhb1-DA8 ade6-M210/ade6-M216 (M27-1)
  13. h- tsc2Tura41 rhb1-DA8 ura4-D18(M47-25)
  14. h- tor2-ts6 rhb1-DA4(M86-20)
  15. tor1Tura41 ura4-D18a (M87-18)
  16. tor1Tura41 rhb1-DA4 ura4-D18a (M87-7)
  17. tor1Tura41 rhb1-DA8 (M88-23)

(1) Nakase Y, et al. 2006. A defect in protein farnesylation suppresses a loss of schizosaccharomyces pombe tsc2+ , a homolog of the human gene predisposing to tuberous sclerosis complex. Genetics 173:596-578.

(2) Murai T, et al. 2009. Distinctive responses to nitrogen starvation in the dominant avtive mutants of the fussion yeast Rheb GTPase. Genetics 183:517-527.

tmatsumo@house.rbc.kyoto-u.ac.jp

TS020021

Elizabeth Henske

S. pombe strains :

  1. h-, Δtsc1::kan+
  2. h-, Δtsc2::kan+
  3. h+, ura4-D18, Δtsc1::kan+
  4. h+, ura4-D18, Δtsc2::kan+
  5. h-, leu1-32, ura-D18, ae6-216, his7-366, Δtsc1::kan+
  6. h-, leu1-32, ura-D18, ae6-216, his7-366, Δtsc2::kan+

van Slegtenhorst M, et al. 2004. Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizo-saccharomyces pombe. Journal of Biological Chemistry 279(13):12706-12713.

ep_henske@fccc.edu

TS020021

Elizabeth Henske

S. pombe strains :

  1. h+, pas1::ura4+, ura4-D18
  2. h-, tsc1::kan+, pas1::ura4+, ura4-D18
  3. h-, tsc2::kan+, pas1::ura4+, ura-D18
  4. h+, leul-32, pas1::ura4+, ura4-D18
  5. h+, leul-32, Δtsc1::kan+
  6. h+, leul-32, Δtsc2::kan+
  7. h+, Rhb1G63D/S165N
  8. h+, Δtsc1::kan+, Rhb1G63D/S165N
  9. h+, Δpas1::ura4+, Rhb1G63D/S165N

van Slegtenhorst M, et al. 2005. Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe. Human Molecular Genetics 14(19):2851-2858.

ep_henske@fccc.edu