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Tuberous Sclerosis Complex
Research Resources Initiative by the TSCRP


The TSCRP now offers a service on our website featuring a listing of newly available TSC research resources! Our goal is to facilitate and speed TSC research by publicizing new resources and aiding collaborations. The list displays available resources and PI contact information. Please contact the PIs directly for information and requests.

Award Number PI Product or Resource References Contact Information or Link
Mouse Models

TS100067

Mark Zervas

Gbx2^(CreER/+);R26^(tdTomato/+);Tsc1^(fl/fl)

Normand EA, et al. 2013. Temporal and mosaic Tsc1 deletion in the developing thalamus disrupts thalamocortical circuitry, neural function, and behavior. Neuron 78:895-909.

For the model or technical assistance, please contact: Mark_Zervas@brown.edu
Individual lines are available from Jackson Labs (http://www.jax.org/): Gbx2^(CreER/+), Stock Number: 022135; R26^(tdTomato/+), Stock Number 007905; Tsc1^(fl/fl), Stock Number 005680

TS093067

Angelique Bordey

Model of tuber-like lesions: Tsc1fl/mut

Feliciano DM, et al. 2011. Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice. Journal of Clinical Investigation 121(4):1596-1607.

angelique.bordey@yale.edu

TS093049

Boyi Gan

Rosa26CreERT2, FoxO1/3/4 L/L, TSC1 L/+ mice

Gan B, et al. 2010. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18:472-484.

bgan@mdanderson.org

TS060030

Michael Gambello

Loss of Tsc2 in Purkinje cells:

  1. Tsc2ko/flox, Pcp2-Cre mice
  2. Tsc2flox/flox, Pcp2-Cre mice

Reith RM, et al. 2011. Loss of the tuberous sclerosis complex protein tuberin causes Purkinje cell degeneration. Neurobiology of Disease 43(1):113-122.

michael.j.gambello@uth.tmc.edu

TS043027

Bo Xiao

Rosa26-Rheb1 S16H and Rosa26-Rheb1 wild type mice

Zou J, et al. 2011. Rheb1 is required for mTORC1 and myelination in postnatal brain development. Developmental Cell 20(1):97-108.

bxiao@jhmi.edu

TS043013

Kiran Chada

  1. Tsc2 +/-, Hmga2 +/- mice
  2. Tsc2 +/-, Hmga2 -/-mice

 

chada@umdnj.edu