A Morpholino Strategy to Assess TSC Gene Function in Zebrafish
Principal Investigator:
BARABAN, SCOTT C
Institution Receiving Award:
CALIFORNIA, UNIVERSITY OF, SAN FRANCISCO
Program:
TSCRP
Proposal Number:
TS050003
Award Number:
W81XWH-06-1-0094
Funding Mechanism:
Concept Award
Partnering Awards:
Award Amount:
$99,999.00
Period of Performance:
10/30/2005 - 11/29/2006
PUBLIC ABSTRACT
Seizures occur in nearly 90% of tuberous sclerosis complex (TSC) patients. Using a simple vertebrate, zebrafish, we will directly address the question of whether seizures are the result of reduced TSC function. Few experimentally useful animal models of TSC are currently available. A zebrafish TSC model can be used to study basic mechanisms underlying seizure genesis (this proposal) or as a system for high-throughput screening of agents that may modify the disease (potential future proposal). This research is important for the vast majority of TSC patients suffering with medically intractable seizure disorders. |
