The STRONG STAR Multidisciplinary PTSD Research Consortium
Principal Investigator:
WILLIAMSON, DOUGLAS E.
Institution Receiving Award:
TEXAS, UNIVERSITY OF, HEALTH SCIENCE CENTER AT SAN ANTONIO
Program:
PH-TBI
Proposal Number:
PT074199P12
Award Number:
W81XWH-08-2-0110
Funding Mechanism:
PTSD Multidisciplinary Research Consortium Award
Partnering Awards:
PT074199, PT074199P13, PT074199P14, PT074199P15, PT074199P17, PT074199P18, PT074199P19, PT074199P20, PT074199P21
Award Amount:
$5,455,048.10
TECHNICAL ABSTRACT
The Genomics Core will carry out a number of integrated studies looking at the interaction of clinical symptoms and syndromes associated with PTSD, treatment response, genetic variants, gene expression analyses, and biochemical and biophysical markers of stress. The overall goal of the Genomics Core is to identify genetic variants and biologic markers which predict onset of PTSD, influence the expression of PTSD, and which moderate response to treatment. The purpose of this study is to determine specific genetic factors that are associated with PTSD in the STRONG STAR cohort, with an ultimate goal of being able to provide pre-exposure screening to characterize those military personnel most at risk to develop the disorder. Genomics Core studies will not be intervention studies, but will analyze naturalistic data to better identify and predict treatment outcomes and to help future design future prevention and intervention studies (beyond the scope of this grant).
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