Prevention of Prostate Cancer Through Understanding Androgen-Induced Oxidative Stress
Principal Investigator:
WILDING, GEORGE
Institution Receiving Award:
WISCONSIN, UNIVERSITY OF, MADISON
Program:
PCRP
Proposal Number:
PC970525
Award Number:
DAMD17-98-1-8505
Funding Mechanism:
Idea Development Award
Partnering Awards:
Award Amount:
$434,487.00
PUBLIC ABSTRACT
Prostate cancer is a disease associated with aging. Also commonly associated with increased aging is a shift in cells of many tissues to a state more susceptible to damage by toxins. We hypothesize that the male hormones, androgens, induce a more damage susceptible state by increasing the concentration of damage-inducing chemical species, called oxidants, in the cells. We have thus far demonstrated that androgens can induce an oxidative stress in human prostate cancer cells and increase oxidative damage. We propose research to determine the source of the oxidants in cells induced by androgens and to examine the intracellular pathways by which androgens signal and produce this genetically damaging stress. Understanding these chemical mechanisms will provide strategies to block the oxidative stress induced by androgens and to use agents such as antioxidants to prevent prostate cancer. |
