Enteric bacteria are essential for the healthy function of the gut as well as in the natural defense mechanisms of the body. However, depending on their composition, they can also cause infection, inflammation, and damage. We have evidence in mice that certain bacterial strains are protective, and when given orally, can help to prevent colon cancer. In this proposal, we will focus on one beneficial bacterial strain, Lactobacillus acidophilus, a major component of the natural beneficial microbiota in the colon. We will investigate which cell surface molecules of L. acidophilus have immune stimulatory properties and which have immune suppressive functions, and how the composite signaling from these molecules works to maintain healthy and protective inflammation in the gut. Using specific genetically modified strains, we will investigate the potential application of the bacteria to reset healthy immunity in colon cancer. The information gained will help to protect against the predisposition for colon cancer and also to complement the standard therapy of established colon cancer. |
