Released: February 10, 2022
Department of Defense
Congressionally Directed Medical Research Programs (CDMRP)
Peer Reviewed Orthopaedic Research Program
Anticipated Funding Opportunities for Fiscal Year 2022 (FY22)
The Fiscal Year 2022 (FY22) Defense Appropriations Bill has not been signed into law. Although FY22 funds have not been appropriated for the Peer Reviewed Orthopaedic Research Program (PRORP), the PRORP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY22 funding opportunities. This pre-announcement should not be construed as an obligation by the government.
The FY22 Defense Appropriations Act is anticipated to provide funding for the PRORP to support high-impact, clinically relevant research to advance optimal treatment and rehabilitation from musculoskeletal injuries. The managing agent for the anticipated program announcements/funding opportunities is the CDMRP at the U.S. Army Medical Research and Development Command (USAMRDC).
The PRORP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY22 funding opportunities. This pre-announcement should not be construed as an obligation by the government. The FY22 PRORP funding opportunity announcements for the following award mechanisms will be posted on the Grants.gov website. Pre-application and application deadlines will be available when the announcements are released.
Applications submitted to the FY22 PRORP must address one or more of the following Focus Areas:
- Compartment Syndrome and/or Reperfusion Injury: Novel treatment strategies to improve current diagnoses for compartment syndrome and/or reperfusion injury. Proposals that address the novel treatment strategies to improve the management of reperfusion injury will be considered. Alternatives to intracompartmental pressure measurements are encouraged.
- Composite Tissue Regeneration: Advanced tissue regeneration therapeutics in composite tissue for the restoration of traumatically injured extremities. Isolated bone, cartilage, muscle, or nerve tissue engineering studies are excluded. Techniques aimed at improving outcomes following high-energy extremity trauma, with a focus on improving wound healing and neuromuscular recovery following composite tissue loss and segmental bone loss, are encouraged.
- Limb Stabilization and Protection: Development and/or clinical evaluation of rapid limb stabilization and novel wound protectants for severely or critically wounded limbs to enable prolonged care and eventual transport to the point of definitive treatment.
- Osseointegration: Identification of best practices to address infection, rejection, and/or failure of percutaneous osseointegrated prosthetic limbs.
- Prostheses and Orthoses: Development of high-performance novel prosthetic or orthotic devices designed to enhance whole-person performance and decrease pain in patients with amputation and limb salvage and impairment. Multicenter studies that focus on transfemoral amputees are encouraged, as are advanced limb orthoses that span at least one major joint (i.e., ankle, knee, and elbow).
- Retention Strategies: Development, optimization, and/or validation of battlefield-feasible diagnostic capabilities, decision support tools, interventions, and/or rehabilitation strategies that can facilitate retention on duty or avoid reinjury for common combat-related musculoskeletal injuries. Biomarker studies are excluded. The current standard of care must be noted. The rehabilitation strategy to be used in the proposed study must be specified, as applicable.
- Battlefield Care: Strategies that can be utilized at or near the point of injury to allow an injured Service Member to remain on the battlefield or on mission without the need for evacuation. Development of novel nerve, soft tissue, muscle, and/or skeletal diagnostic capabilities at the point of injury (near battlefield) for diagnosis of underlying pathology and efficacy of interventions. Treatment strategies that allow return to mission effectiveness within 30 days will be considered.
- Return to Duty: Treatment strategies that can be utilized along the continuum of care and enable return to duty of the Service Member within 1 year of injury.
- Soft Tissue Trauma: Strategies to develop and/or identify musculoskeletal extremity soft tissue trauma treatments for shoulder, knee, or chronic ankle instability and sequela only to optimize return to duty, work, or reintegration.
- Fracture-Related Infection: Strategies to decrease the burden of fracture-related infections (may include prevention, early detection, or improved eradication). Alternatives to systemic antibiotic delivery are encouraged. Novel approaches that improve the current standard of treatment to prevent fracture-related infections are encouraged.
|Award Mechanism||Eligibility||Key Mechanism Elements||Funding|
|Applied Research Award||Independent investigators at all academic levels (or equivalent) are eligible to submit applications.||
|Clinical Trial Award||Independent investigators at all academic levels (or equivalent) are eligible to submit applications.||
|Clinical Translational Research Award||Independent investigators at all academic levels (or equivalent) are eligible to submit applications.||
A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final funding opportunity announcements that will be available for downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.
Submission deadlines are not available until the funding opportunity announcements are released. For email notification when announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the PRORP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.army.mil).
Point of Contact:
CDMRP Public Affairs
Last updated Thursday, February 10, 2022