DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS
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NEWS RELEASE

Released: March 3, 2015

Defense Health Program
Department of Defense Peer Reviewed Medical Research Program
Funding Opportunities for Fiscal Year 2015 (FY15)

The Fiscal Year 2015 (FY15) Defense Appropriations Act provides $247.5 million to the Department of Defense Peer Reviewed Medical Research Program (PRMRP). The vision of the PRMRP is to improve the health and well-being of all military Service Members, Veterans, and beneficiaries. The PRMRP challenges the scientific and clinical communities to address one of the FY15 congressionally directed topic areas with original ideas that foster new directions in basic science and translational research; novel product development leading to improved therapeutic or diagnostic tools; synergistic, multidisciplinary research program; or clinical trials that address an immediate clinical need.

As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency, Research, Development, and Acquisition (DHA RDA) Directorate manages and executes the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The executing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP).

The PRMRP is providing the information in this pre-announcement to allow investigators time to plan and develop applications. FY15 PRMRP Program Announcements and General Application Instructions are anticipated to be posted on Grants.gov by late March or early April 2015. Pre-application and application deadlines will be available when the Program Announcements are released. This pre-announcement should not be construed as an obligation by the government.

Congressionally Directed Topic Areas. The FY15 PRMRP will solicit research applications for the following 41 topics areas:

  • Acupuncture
  • Acute Lung Injury
  • Advanced Prosthetics
  • Arthritis
  • Burn Pit Exposure
  • Cardiovascular Health
  • Chronic Migraine and Post-Traumatic Headaches
  • Congenital Heart Disease
  • Dengue
  • Diabetes
  • DNA Vaccine Technology for Postexposure Prophylaxis
  • Dystonia
  • Focal Segmental Glomerulosclerosis
  • Food Allergies
  • Fragile X Syndrome
  • Healthcare-acquired Infection Reduction
  • Hepatitis B
  • Hereditary Angioedema
  • Hydrocephalus
  • Inflammatory Bowel Disease
  • Integrative Medicine
  • Interstitial Cystitis
  • Lupus
  • Malaria
  • Metals Toxicology
  • Mitochondrial Disease
  • Nanomaterials for Bone Regeneration
  • Osteoarthritis
  • Pancreatitis
  • Pathogen-inactivated Dried Plasma
  • Polycystic Kidney Disease
  • Post-Traumatic Osteoarthritis
  • Psychotropic Medications
  • Pulmonary Fibrosis
  • Respiratory Health
  • Rheumatoid Arthritis
  • Scleroderma
  • Sleep Disorders
  • Tinnitus
  • Vascular Malformations
  • Women's Heart Disease

Military Relevance: Relevance to the healthcare needs of the military Service Members, Veterans, and beneficiaries is a key feature of each FY15 PRMRP award mechanism.

Award Mechanism Eligibility Key Mechanism Elements Funding
Clinical Trial Award Assistant Professor level or above (or equivalent)
  • Supports the rapid implementation of clinical trials of novel interventions with the potential to have a significant impact on patient care in the topic area(s) of interest
  • Proposed projects may range from small proof-of-concept trials through large-scale, definitive trials
  • Investigational New Drug or Investigational Device Exemption applications, if needed, should be submitted to the Food and Drug Administration before the PRMRP Grants.gov application submission deadline
  • Preproposal submission is required; application submission is by invitation only
  • Funding limit not defined; requested funding must be appropriate for the scope of work proposed
  • Maximum period of performance is 5 years
Discovery Award All Investigators
  • Supports the exploration of a highly innovative new concept or untested theory
  • Not intended to support the logical progression of an already established line of questioning
  • Clinical trials will not be funded
  • Reviewers will be blinded to the identity of the PI, collaborators, and their organization(s)
  • Maximum of $200,000 for direct costs (plus indirect costs)
  • Maximum period of performance is 18 months
Focused Program Award Full Professor level or above (or equivalent)
  • Restricted to the topic areas of Acupuncture, Advanced Prosthetics, Burn Pit Exposure, Cardiovascular Health, Congenital Heart Disease, Focal Segmental Glomerulosclerosis, Healthcare-acquired Infection Reduction, Hepatitis B, Hydrocephalus, Integrative Medicine, Metals Toxicology, Mitochondrial Disease, Nanomaterials for Bone Regeneration, Osteoarthritis, Pathogen-inactivated Dried Plasma, Pulmonary Fibrosis, Psychotropic Medications, Respiratory Health, Sleep Disorders, Vascular Malformations, and Women's Heart Disease
  • Supports a synergistic, multidisciplinary research program of at least four distinct but complementary projects addressing an overarching goal in one of the topic areas listed directly above
  • Projects should work together to answer critical questions, resolve differing hypotheses, and translate laboratory findings to clinical applications
  • Projects may range from exploratory/hypothesis-developing through small-scale clinical trials that together will address the overarching goal/question
  • Research team of highly qualified, multidisciplinary project leaders should be led by a Principal Investigator with demonstrated success in directing large, focused projects
  • Preproposal submission is required; application submission is by invitation only
  • Maximum of $10 million for total costs (includes direct and indirect costs)
  • Maximum period of performance is 5 years
Investigator-Initiated Research Award Assistant Professor level or above (or equivalent)
  • Supports research that will make an original and important contribution to the field of research or patient care in the topic area(s) of interest
  • Partnering Principal Investigator (PI) Option available
  • Clinical trials will not be funded
  • Preproposal submission is required; application submission is by invitation only
  • Maximum of $1.2 million for direct costs (plus indirect costs)
  • Maximum of $1.5 million for direct costs (plus indirect costs) for applications including a Partnering PI Option
  • Maximum period of performance is 3 years
Technology/ Therapeutic Development Award Assistant Professor level or above (or equivalent)
  • Supports the development of diagnostics or therapies that have the potential to make a strong impact on patient care in the topic area(s) of interest
  • Product-oriented: device, drug, clinical guidelines
  • Clinical trials will not be funded
  • Preproposal submission is required; application submission is by invitation only
  • Maximum of $1.8 million for direct costs (plus indirect costs)
  • Maximum period of performance is 3 years

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions that will be available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

Applications must be submitted through the federal government's single-entry portal, Grants.gov. Submission deadlines are not available until the Program Announcements are released. Requests for email notification of the Program Announcements release may be sent to help@eBRAP.org.

For more information about the PRMRP or other CDMRP-administered programs, please visit the CDMRP website (https://CDMRP.HEALTH.MIL).

Point of Contact:

CDMRP Public Affairs
301-619-9783
usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@mail.mil