DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS
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NEWS RELEASE

Released: April 30, 2012

Department of Defense Peer Reviewed Orthopaedic Research Program
Funding Opportunities for Fiscal Year 2012

The Fiscal Year 2012 (FY12) Defense Appropriations Act provides $30 million (M) to the Department of Defense Peer Reviewed Orthopaedic Research Program (PRORP). The PRORP seeks to fund innovative, high-impact, clinically relevant research to advance optimal treatment and rehabilitation from musculoskeletal injuries sustained during combat or combat-related activities. This program is administered by the US Army Medical Research and Materiel Command through the Office of the Congressionally Directed Medical Research Programs (CDMRP).

The FY12 PRORP Focus Areas are:

  • Improvement of moisture management and residual limb skin care at the prosthetic socket interface.
  • Improvement of the rate of nerve regeneration.
  • Strategies to inhibit neuromas at surgical/amputation sites.
  • The treatment of segmental bone injury in weight-bearing locations, including utilization of the Masquelet technique for bioactive membrane formation and identification of the best bone graft options. Clinical and mature translational studies only; development of novel bone void filler products are not of interest.
  • The comparative effectiveness of local strategies to minimize surgical site infection, including local application of antibiotics, debridement techniques, and subatmospheric wound dressings.
  • Treatment and management of heterotopic ossification. Mature translational studies only; the development and/or validation of new animal models of heterotopic ossification are not of interest.
  • Mitigation of the negative effects of immobility for polytrauma patients, excluding spinal cord injury.
  • Short-term and long-term outcomes in limb salvage populations.
  • Prevention or treatment of post-traumatic joint stiffness and contracture in the ankle, knee, and/or elbow.

All applications are required to address at least one Focus Areas as specified in each program announcement. Note that Focus Areas may differ between program announcements/funding opportunities. Full details of FY12 PRORP Focus Areas will be included in the program announcements when they are released.

FY12 PRORP program announcements and application instructions for the following award mechanisms (including deadlines) are anticipated to be posted and available for download on Grants.gov in mid May 2012.

Award Mechanism Eligibility Key Mechanism Elements Funding
Clinical Trial Award Independent Investigators at or above the level of Assistant Professor (or equivalent)
  • Preproposal is required; application submission is by invitation only
  • Supports the rapid implementation of clinical trials that will have a significant impact on military combat-related orthopaedic injuries
  • Preliminary data are required
  • Military/Veteran study population highly encouraged
  • Nested Career Development Option: Additional funds may be requested to support the mentored career development of an active duty military research- or physician-scientist at an early career stage.
  • Maximum funding of $2.5M for direct costs (plus indirect costs)
  • Period of performance up to 5 years
  • Nested Career Development: Additional direct costs of $225K for total combined direct costs of $2.725M
Translational Research Partnership Award Independent investigators at all academic levels (or equivalent)
  • Preproposal is required; application submission is by invitation only
  • Supports the development of multidisciplinary translational research partnerships between clinicians and laboratory scientists to accelerate the movement of promising research hypotheses into clinical applications
  • Minimum of 2 PIs required; maximum of 3 PIs allowed
  • At least one partner must be a laboratory scientist and at least one partner must be a clinician
  • At least one partner must have significant experience in orthopaedic research or orthopaedic medicine
  • Preliminary and/or published data are required
  • Does not support definitive clinical trials, but limited clinical testing is permissible
  • All applications must have a direct relevance to orthopaedic injuries sustained during combat or combat-related activities
  • Nested Career Development Option: Additional funds may be requested to support the mentored career development of an active duty military research- or physician-scientist at an early career stage
  • Maximum combined funding of $750K for direct costs (plus indirect costs)
  • Period of performance up to 3 years
  • Nested Career Development: Additional direct costs of $225K for total combined direct costs of $975K
Idea Development Award Independent investigators at all academic levels (or equivalent)
  • Supports conceptually innovative, high-risk/high gain research
  • Emphasis is on Innovation and Military Benefit
  • Preliminary data are not required
  • Clinical trials not allowed
  • Nested Career Development Option: Additional funds may be requested to support the mentored career development of an active duty military research- or physician-scientist at an early career stage
  • Maximum funding of $500K for direct costs (plus indirect costs)
  • Period of performance up to 3 years
  • Nested Career Development: Additional direct costs of $225K for total combined direct costs of $725K

Information in this press release is being provided to allow investigators time to plan and develop proposals. All applications submitted must conform to the final program announcements, which will be posted on Grants.gov and the CDMRP website (https://CDMRP.HEALTH.MIL) at a later date. Submission deadlines are not available until the program announcements are released.

A pre-application (preproposal) is required and must be submitted through the CDMRP eReceipt website (http://cdmrp.org) prior to proposal submission. Applications must be submitted through the federal government's single-entry portal, Grants.gov. Individual program announcements and required forms will also be found on the Grants.gov website.

Requests for email notification of the release of program announcements may be sent to Help@cdmrp.org. Email notifications of funding opportunities are sent as a courtesy and should not be used as a sole source of notification; applicants should monitor Grants.gov for official postings of funding opportunities.

For more information about the PRORP or other CDMRP-administered programs, please visit the CDMRP website (https://CDMRP.HEALTH.MIL).

Point of Contact:

CDMRP Public Affairs
301-619-9783
CDMRP.PublicAffairs@amedd.army.mil