IMPORTANT: The FY11 PCRP will use two Overarching Challenges and six Focus Areas to direct/frame applications for funding:
- Overarching Challenges: Development of effective treatments for advanced prostate cancer, Distinguish aggressive from indolent disease
- Focus Areas: Biomarkers, Genetics, Imaging, Survivorship, Therapy, Tumor Biology and Immunology
|
| RESEARCH AWARDS |
| Award Mechanism |
Eligibility |
Key Mechanism Elements |
Funding |
| Clinical Trial Award |
Independent investigators at or above the level of Assistant Professor (or equivalent)
|
- Preproposal is required; application submission is by invitation only
- Supports rapid execution of early phase clinical trials that have the potential for significant impact on prostate cancer
- Studies may include evaluation of novel drug , biologic, device, surgical procedure, rehabilitative modality, behavioral or other intervention
- Clinical trials are expected to be initiated upon receipt of award
- Studies requiring funding in excess of the DOD award must provide evidence of the availability of such funding
- If applicable, IND or IDE approval must be received prior to applying for this award
- Preliminary data and clinical protocol are required
|
- Maximum funding of $375K for direct costs (plus indirect costs)
- Period of performance cannot exceed 3 years
|
| Exploration-Hypothesis Development Award |
Investigators at all academic levels (or equivalent)
|
- Supports highly innovative, untested, potentially groundbreaking concepts in prostate cancer
- Emphasis is on innovation; potential impact may be unknown
- Studies involving human subjects are permitted provided they are exempt from or qualify for expedited IRB review
- Preliminary data are not allowed
|
- Maximum funding of $75K for direct costs (plus indirect costs)
- Period of performance cannot exceed 12 months
|
| Health Disparity Research Award |
Independent investigators at or above the level of Assistant Professor (or equivalent); or
New Investigator Option: PIs must meet the following criteria by the application submission deadline:
- Must have the freedom to pursue individual aims without formal mentorship, AND
- Have not previously received a PCRP New Investigator Award, AND
- Either have completed at least 3 years of postdoctoral training OR are within 5 years of having received first independent faculty position (or equivalent)
|
- Supports high-impact approaches to prostate cancer health disparity research that represent new ideas and, if successful, will significantly accelerate the elimination of death and suffering from prostate cancer
- Member(s) of the research team should have a connection to, or effectiveness in working with, a disproportionately affected population or community
- New Investigator Option supports applicants early in their faculty appointments or in the process of developing
- Qualified Collaborator Option (QCO) qualifies studies for higher level of funding
- Preliminary data are encouraged but not required
- Clinical trials are not allowed
|
- Maximum funding of $450K (or $600K for QCO) for direct costs (plus indirect costs)
- Period of performance cannot exceed 3 years
|
| Idea Development Award |
Independent investigators at or above the level of Assistant Professor (or equivalent); or
New Investigator Option: PIs must meet the following criteria by the application submission deadline:
- Must have the freedom to pursue individual aims without formal mentorship, AND
- Have not previously received a PCRP New Investigator Award, AND
- Either have completed at least 3 years of postdoctoral training OR are within 5 years of having received first independent faculty position (or equivalent)
|
- Preproposal is required; application submission is by invitation only
- Supports new ideas that represent innovative, high-risk/high-gain approaches to prostate cancer research and, if successful, will significantly accelerate the elimination of death and suffering from prostate cancer
- New Investigator Option supports applicants early in their faculty appointments or in the process of developing independent research careers
- Preliminary data are encouraged but not required
- Clinical trials are not allowed
|
Established PIs (revised!):
- Maximum funding of $375K for direct costs (plus indirect costs)
- Period of performance cannot exceed 3 years
New Investigator Option (revised!):
- Maximum funding of $225K for direct costs (plus indirect costs)
- Period of performance cannot exceed 3 years
|
| Impact Award |
Independent investigators at or above the level of Assistant Professor (or equivalent)
|
- Preproposal is required; application submission is by invitation only
- Supports high-impact studies towards reducing or eliminating the problem of overtreatment of primary prostate cancer
- Areas of special interest include but are not limited to active surveillance, biomarkers, improved staging, local staging, and optimal measures for follow-up and biopsy
- Multidisciplinary teams inclusive of strong clinical expertise are a key feature
- Preliminary data to support feasibility are required
- Allows clinical trials
|
- Maximum funding of $750K for direct costs (plus indirect costs)
- Period of performance cannot exceed 4 years
|
| Laboratory-Clinical Transition Award |
Independent investigators at or above the level of Assistant Professor (or equivalent)
|
- Preproposal is required; application submission is by invitation only
- Supports goal- and product-driven preclinical studies of promising lead agents to IND and/or cGMP production that may revolutionize prostate cancer clinical care
- PIs are expected to have identified and have access to either one lead agent or a limited number of lead agents and a validated target before applying
- Preliminary data are required to demonstrate target availability and relevance to human prostate cancer and lead agent(s) mechanism of action and potential efficacy
- Clinical trials are not allowed
|
- Maximum funding of $750K for direct costs (plus indirect costs)
- Period of performance cannot exceed 3 years
|
| Population-Based Research Award |
Independent investigators at or above the level of Assistant Professor (or equivalent)
|
- Supports high-impact approaches to prostate cancer research from the perspective of population-based studies that will, if successful, significantly accelerate the elimination of death and suffering from prostate cancer
- Population-based studies may include retrospective, prospective, case-control, cohort or other population-based study designs provided that the study population is of sufficient size to provide appropriate statistical power
- Topics may include but are not limited to epidemiology, molecular genetics, genomics, risk prediction, disease aggressiveness, predictors of therapeutic response and progression, and health disparity
- Requires a robust statistical plan and strong biostatistical expertise on the study team
- Clinical trials are not allowed
|
- Maximum funding of $600K for direct costs (plus indirect costs)
- Period of performance cannot exceed 4 years
|
| Synergistic Idea Development Award |
Two or three independent investigators at or above the level of Assistant Professor (or equivalent)
|
- Preproposal is required; application submission is by invitation only
- Supports new or existing partnerships between two or three independent investigators to address a central innovative question in prostate cancer that may include high risk, provided there is a potential for significant impact
- Preliminary data are encouraged but not required
- Clinical trials are not allowed
|
- Maximum combined funding of $750K for direct costs (plus indirect costs)
- Period of performance cannot exceed 3 years
|
| Collaborative Undergraduate Historically Black Colleges and Universities (HBCU) Student Summer Training Program Award |
Independent investigators at or above the level of Assistant Professor (or equivalent) with a proven record in prostate cancer research and training
|
- Supports new or existing summer prostate cancer training programs for undergraduate HBCU students at host institutions
- Must enroll a minimum of four undergraduate HBCU trainees per year
- Host institution must have a record of achievement in prostate cancer research and training
|
- Maximum funding of $185K for direct costs (plus 8% indirect costs)
- Period of performance cannot exceed 3 years
|
| Health Disparity Training Award |
Predoctoral Ph.D. and M.D./Ph.D. PIs:
- Must be enrolled full-time in an accredited doctoral program and must have completed all predissertation requirements by October 1, 2011
Postdoctoral Ph.D. and M.D. PIs:
- Must have successfully defended a doctoral thesis or possess and M.D. by October 1, 2011; and
- Have 3 years or less of postdoctoral fellowship experience by October 1, 2011; and
- Be able to devote at least 40% effort
|
- Supports training in prostate cancer health disparity research for individuals in the early stages of their careers
- PIs must have a designated mentor who is an experienced prostate cancer health disparity researcher
- PI or mentor must demonstrate a connection to, or effectiveness in working with, the disproportionately affected population or community
|
Predoctoral Ph.D. and M.D./Ph.D. PIs:
- Maximum funding of $92.5K for direct costs (plus 8% indirect costs)
- Period of performance cannot exceed 3 years
Postdoctoral Ph.D. and M.D. PIs:
- Maximum of $115K for direct costs (plus 8% indirect costs)
- Period of performance cannot exceed 2 years
|
| Physician Research Training Award |
At the time of proposal submission, the PI must be either:
- A physician with clinical duties and/or responsibilities in the last year of an accredited medical residency or medical fellowship program; or
- A physician within 3 years of first independent faculty appointment
|
- Supports training of physicians with clinical duties for careers in prostate cancer research
- Individualized training program and mentorship should prepare the PI for an independent career as a leader in prostate cancer research
- Institutions must provide at least 40% protection of PI's time for research
|
- Maximum funding of $130K per year for direct costs (plus 8% indirect costs)
- Period of performance is 3 years minimum to 5 years maximum
|
| Postdoctoral Fellowship Award |
- Must have successfully defended a doctoral thesis or possess an M.D. (or equivalent) by October 1, 2011; and
- Have 3 years or less of postdoctoral fellowship experience by October 1, 2011; and
- Be able to devote at least 40% effort
|
- Supports prostate cancer research training for talented individuals in the early stages of their careers
- Individualized training program and mentorship should prepare the PI for an independent career as a leader in prostate cancer research
|
- Maximum of $115K for direct costs (plus 8% indirect costs)
- Period of performance cannot exceed 2 years
|
