Neurofibromatosis
Research Highlights/News
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2024
Press Releases:
- Department of Defense Neurofibromatosis Research Program Anticipated Funding Opportunities for Fiscal Year 2024 (FY24)
March 27, 2024
Research Highlights:
- New Investigator Award Recipients Bring New Ideas to the Neurofibromatosis Research Program for Fiscal Year 2022
- Sleep Disorders Among Children with Neurofibromatosis Type 1 (NF1)
2023
Press Releases:
- Department of Defense Neurofibromatosis Research Program Anticipated Funding Opportunities for Fiscal Year 2023 (FY23)
April 14, 2023
Research Highlights:
- Improving Hearing in NF2 Patients Who Use the Auditory Brainstem Implant (ABI)
- Development of Therapeutic Strategies for NF1-Associated Optic Pathway Glioma
- NFRP Supports Multi-Institutional Synergistic Idea Award to Investigate Inflammation During NF-Related Optic Tumor Formation
- NFRP Funds First Research OTA to Support Neurofibromatosis Clinical Trials
2022
Press Releases:
- Department of Defense Neurofibromatosis Research Program Anticipated Funding Opportunities for Fiscal Year 2022 (FY22)
March 7, 2022
Research Highlights:
- Neurofibromatosis Research Program (NFRP) Research Resources
- Genetic Risk Factors of Schwannoma Tumors
- Pharmacological Alk Inhibition Impacts Behavior and Cognition in Adult NF1 Mutant Mice
2021
Press Releases:
- Department of Defense Neurofibromatosis Research Program Anticipated Funding Opportunities for Fiscal Year 2021 (FY21)
February 4, 2021
Research Highlights:
- Nf1 Mutation Drives Neuronal-Activity-Dependent Initiation of Optic Glioma
- New Investigator Award Recipients Bring New Ideas to the Neurofibromatosis Research Program for Fiscal Year 2020
- Cabozantinib for Neurofibromatosis Type 1-Related Plexiform Neurofibromas: A Phase 2 Trial
- Everolimus Therapy for NF1-Optic Gliomas in Children: A Clinical Trial
News:
- Stem Cells May Explain Why Rare Inherited Tumor in Kids Is So Aggressive (external link)
Memorial Sloan Kettering Cancer Center, September 1, 2021 - Study demonstrates efficacy of new treatment for neurofibromatosis type1-related tumors (external link)
Children's Hospital of Philadelphia, February 12, 2021
2020
Research Highlights:
- The Pain of Neurofibromatosis
- The NFRP Supports the Future of NF Research with Several New Investigator Awards
- The NFRP Joins Efforts to Promote Open Science in NF Research
- Clinical Trials Address Quality of Life for Persons with Neurofibromatosis (NF1, NF2, and Schwannomatosis) with Resiliency Training Delivered via Live Video
- Study Finds That Bevacizumab Treatment for NF2-Related Vestibular Schwannomas Increases Reported Quality of Life in Adults and Children
2019
Press Releases:
- Department of Defense Neurofibromatosis Research Program Anticipated Funding Opportunities for Fiscal Year 2020 (FY20)
December 17, 2019 - Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2019 (FY19)
February 25, 2019
Research Highlights:
- The NFRP Presents the Fiscal Year 2018 Early Investigator Research Award Recipients
- The NFRP Presents the Fiscal Year 2018 New Investigator Award Recipients
- Investigating the Role of Fibroblasts in the Tumor Microenvironment and Hippo Signaling Pathway in Neurofibromas
- Cerebellopontine Angle (CPA) Model: A Novel Tool for Investigating Immunotherapy in Neurofibromatosis Type 2 Vestibular Schwannomas
- Fiscal Year 2017 New Investigator Award Recipients
- Bench to Bedside - Collaborating to Develop Effective Therapies for NF
- Pathophysiology and Treatment of Muscle Weakness in NF1
Video Highlights:
2018
Press Releases:
- Department of Defense Neurofibromatosis Research Program Anticipated Funding Opportunities for Fiscal Year 2018 (FY18)
March 26, 2018
Research Highlights:
- Identification of Molecular and Cellular Contributions to Neurofibroma Formation and Growth
- Fiscal Year 2016 New Investigator Award Recipients
- Potential Therapeutics for Neurofibromatosis Type 2-Associated Schwannoma Tumors
- Identification of Novel Therapeutic Targets for NF1 Optic Pathway Glioma by Examining the Tumor as an Ecosystem
Video Highlights:
2017
Press Releases:
- Department of Defense Neurofibromatosis Research Program Anticipated Funding Opportunities for Fiscal Year 2017
February 23, 2017
Research Highlights:
- Decreasing the Clinical Impact of Neurofibromatosis New Clinical Trials Funded Through the Neurofibromatosis Research Program
- Deletion of Anaplastic Lymphoma Kinase improves cognitive impairments in a mouse model of Neurofibromatosis Type 1
- Study Finds that Lovastatin is Not Effective for Treating Learning or Attention Impairments in Children with NF1
- Opioid Receptor Signaling Crosstalk to Ras Protein is Mediated by Neurofibromin 1
2016
Research Highlights:
- FY15 New Investigator Award Recipients
- Finding New Targets for Treatment of NF2-Deficient Meningiomas
- Combined mTORC1 and MEK Inhibition Leads to Regression of NF1-Mutant Cancers
2015
Press Releases:
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2016 December 3, 2015
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2015 March 2, 2015
Research Highlights:
- FY14 NFRP New Investigator Award Recipients
- Kathryn North: Neurocognitive Assessment of Young Children with NF1
- Functional Characterization of a Novel NF2/Merlin Protein Complex in Growth Control
2014
Press Releases:
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2014 January 31, 2014
Research Highlights:
- Improving Cognitive and Behavioral Function in Nf1 Genetically-Engineered Mice
- Oncolytic Herpes Simplex Virus Vectors Expressing Therapeutic Transgenes for the Treatment of NF1 Tumors
- Cell of Origin and Microenvironment Contribution in NF1-associated Peripheral Nerve Sheath Tumor Development
- Preclinical Murine Model for Fracture Healing in NF1
2013
Press Releases:
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2013 April 15, 2013
Research Highlights:
- Characterization of an NF2 Model that Develops Intracranial Vestibular Schwannomas and Meningiomas Associated with Hearing Loss
- MEK Inhibition Prevents Brain Abnormalities Associated with NF1
- MEK Inhibition Exhibits Efficacy in Human and Mouse Neurofibromatosis Tumors
- Mouse Model of Schwannomatosis-Related Neuropathic Pain
News:
-
'Merlin' is a matchmaker, not a magician (external link)
Johns Hopkins Medicine, September 13, 2013 -
House Research Institute Recruiting Patients for Clinical Trial of Medication to Treat NF2 Tumors (external link)
House Research Institute, April 8, 2013
2012
Press Releases:
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2012 February 1, 2012
Research Highlights:
- Genetic and Epigenetic Differences in Monozygotic Twins with NF1
- Neurofibromatosis Clinical Trials Consortium
- Improving Cognitive and Behavioral Function in NF1 Genetically Engineered Mice
- Defining Quality of Life in NF2
News:
-
Mechanisms Underlying Childhood Neuromuscular Disease SMA Found (external link)
Columbia University Medical Center, October 18, 2012 -
Heat-shock factor reveals its unique role in supporting highly malignant cancers (external link)
Whitehead Institute for Biomedical Research, August 8, 2012 -
NFRP Grant Enables Consortium to Launch Clinical Trials (external link)
The University of Alabama at Birmingham, July 11, 2012
Video Highlights:
2011
Research Highlights:
News:
-
Brain Scans Reveal Drugs' Effects on Attention(external link)
Washington University in St. Louis, October 13, 2011
2010
Press Releases:
- Department of Defense Neurofibromatosis Research Program Anticipated Funding Opportunities for Fiscal Year 2011 December 20, 2010
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2010 January 7, 2010
Research Highlights:
- Induced Pluripotent Stem Cells as Potential Therapeutic Agents in NF1
- Identification of the Cellular and Molecular Mechanisms Underlying the Osseous Manifestations of NF1 in Murine and Human Systems
- Characterizing KEN: A Novel NF2/Merlin Protein Complex Modulating Growth Control
- Identification of a New Target and Treatment Compound for NF1-Associated Cancer
2009
Research Highlights:
- Congressionally Directed Medical Research Program (CDMRP)-Funded Research Presented at the 2009 Neurofibromatosis (NF) Conference
- Hu is Making the Decisions?
- Mouse Model Replicates Skeletal Abnormalities of Neurofibromatosis Type I
- Finding the Positive in Negative Feedback
News:
-
Protein Role in NF Immune Function
(external link)
Published: October 29, 2009
2008
Press Releases:
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2009 November 13, 2008
Research Highlights:
- A Pain in the Neuroma: Using a New Pain Model to Find Ways to Stop the Vicious Cycle
- Molecular Mechanism of NF1 Vasculopathy
- Neurofibromin Ubiquitin Ligase: Regulation and Function
- New Hope from a Glimmer: Photodynamic Therapy for the Treatment of Plexiform Neurofibromas
- Functional Role of Merlin in Meningioma Cells
- Using Modified Oncolytic Herpes Simplex Virus (HSV) to Treat NF2 Tumors
- Understanding the Pathogenesis of Skeletal Manifestations of NF1 Patients
- Functional Analysis of Drosophila NF1
News:
-
Researchers Identify Drug Treatment for Neurofibromatosis
(external link)
Published: October 30, 2008 -
NF1 Malignant Cells Identified
(external link)
Published: February 4, 2008
2007
Press Releases:
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2008 December 19, 2007
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2007 January 5, 2007
Research Highlights:
News:
-
NF1: Cancer Gene Drives Pivotal Decision
(external link)
Published: November 12, 2007 -
Existing Drugs May Treat Brain Tumors Effectively
(external link)
Published: October 15, 2007 -
$5.7 Million NF Consortium Grant for Clinical Trials
(external link)
Published: October 2, 2007
2006
Press Releases:
- Neurofibromatosis Research Program Funding Opportunities Pre-Announcement for Fiscal Year 2006 January 9, 2006
Research Highlights:
- Insights into Neurofibromatosis-Associated Pain
- Chipping Away at the Origin of Malignant Peripheral Nerve Sheath Tumors
- Identifying Novel Functions of Neurofibromin
2005
Press Releases:
- NF Plans Additional Call for Proposals in 2005 December 1, 2005
- Mice provide insight into therapy-induced cancers in humans October 17, 2005
Research Highlights:
- Understanding NF2 Clinical Variability
- Phase II trials Underway for NF1 Treatment
- Improving Ras-Targeted Treatment Approaches for NF1 Tumors
- A New Model for Merlin Localization and Function
News:
-
New Therapeutic Target for NF 1
(external link)
Published: October 31, 2005 -
Study Reveals Why Treatment Efforts Fail in NF1
(external link)
Published: January 3, 2005
2004
Press Releases:
Research Highlights:
- Dissecting the Molecular and Genetic Mechanisms of Neurofibroma Formation in NF1
- Targeting Angiogenesis for the Treatment of NF1 Tumors
- Mitochondrial Aberrations in NF1 Tumors - A Potential Explanation for Disease Variability?
2003
Press Releases:
- Department of Defense Neurofibromatosis Research Program Funding Opportunities for Fiscal Year 2004 December 24, 2003
- Department of Defense Neurofibromatosis Research Awards September 10, 2003
Research Highlights:
News:
2002
Press Releases:
Research Highlights:
- Targeting Cellular Signaling Pathways to Inhibit the Growth of NF1 Tumors
- Many Types of NF1 Mutations Can Lead to the Development of Tumors in NF1 Patients
- Elucidating the Relationship between Learning Deficits and the NF1 Gene
- Elucidating the Functions of the Nf2 Gene
2001
Press Releases:
Research Highlights:
News:
- Jones, Dilys "House Ear Institute Receives over $10M In Research Grants", press release of the House Ear Institute.
Published: April 15, 2001
Scientists and physicians at the House Ear Institute (HEI) were awarded nine different research grants totaling more than
$10 Million in the first quarter of 2001.
https://groups.google.com/forum/#!topic/alt.support.hearing-loss/vNv8Cvasvc8
2000
Press Releases:
- FY00 Neurofibromatosis Research Program Announcement April 7, 2000
1999
Press Releases:
- FY98 Neurofibromatosis Research Program Awards Summary October 14, 1999
Last updated Tuesday, October 8, 2024