Reconstructive Transplant Research
NEWS RELEASE
Released: May 16, 2022
Department of Defense
Congressionally Directed Medical Research Programs (CDMRP)
Reconstructive Transplant Research Program (RTRP)
Anticipated Funding Opportunities for Fiscal Year 2022 (FY22)
The FY22 Defense Appropriations Act provides funding for RTRP to support research of exceptional scientific merit to refine approaches for and increase access to reconstructive transplants and state-of-the-art immunotherapy. The managing agent for the anticipated program announcements/funding opportunities is the CDMRP at the U.S. Army Medical Research and Development Command (USAMRDC).
The RTRP is providing the information in this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY22 funding opportunities. This pre-announcement should not be construed as an obligation by the government. The FY22 RTRP funding opportunity announcements for the following award mechanisms will be posted on the Grants.gov website. Pre-application and application deadlines will be available when the announcements are released.
Applications submitted to the FY22 RTRP Investigator-Initiated Research Award must address one or more of the following Focus Areas:
Reduce the risks of vascularized composite allotransplantation (VCA)-associated immunosuppression
- Define the unique manifestations and/or mechanisms of VCA immunogenicity
- Develop novel approaches for achieving VCA immune tolerance
- Develop less-toxic and/or personalized regimens for maintenance immunosuppression
- Identify unique immunosuppression requirements for VCA compared to other solid organ transplants
Identify and/ or validate reliable non-invasive prognostic/diagnostic biomarkers, methods, or tools for monitoring VCA graft rejection, including applications that would be suitable for point-of-care testing or home monitoring
- Identify and/or validate reliable non-invasive biomarkers for monitoring acute and chronic VCA graft rejection in human subjects or banked human specimens and medical records suitable for use in the clinic or at home
- Develop assays or devices for clinical graft monitoring utilizing validated biomarkers
Develop VCA-specific outcome measures to include:
- Measures of clinical outcomes, including but not limited to, graft health and survival, frequency and/or severity of graft rejections, immunosuppression-related toxicity
- Measures of functional outcomes, including but not limited to, neuromusculoskeletal function, range of motion, resolution of phantom limb pain
- Measures of social outcomes, including but not limited to, activities of daily living, return to work, community integration, VCA-specific quality of life measures
Applications submitted to the FY22 RTRP Advanced Technology Development Award must address one or more of the following Focus Areas:
Advance existing tissue preservation strategies to extend the timeline between procurement and transplantation
- Develop promising approaches and technologies for translation to the clinic, including but not limited to, perfusion, hypothermic, high-subzero and low-subzero, or static preservation strategies
- Determine the extent to which VCA tissue preservation technology impacts VCA immunogenicity
Advance reliable non-invasive prognostic/diagnostic biomarkers, methods, or tools for monitoring VCA graft rejection, including applications that would be suitable for point-of-care testing or home monitoring
- Validate reliable non-invasive biomarkers for monitoring acute and chronic VCA graft rejection in a human model or banked human specimens and medical records
- Develop assays or devices for clinical implementation of graft monitoring utilizing validated biomarkers
Applications submitted to the FY22 RTRP Concept Award must address one or more of the following Focus Areas:
Reduce the risks of VCA-associated immunotherapy
- Define the unique manifestations and/or mechanisms of VCA immunogenicity
- Develop novel approaches for achieving VCA immune tolerance
- Develop less-toxic and/or personalized regimens for maintenance immunosuppression
- Identify unique immunosuppression requirements for VCA compared to other solid organ transplants
Identify reliable non-invasive prognostic/diagnostic biomarkers, methods, or tools for monitoring VCA graft rejection, including applications that would be suitable for point-of-care testing or home monitoring
- Identify new peripheral biomarkers for acute and chronic VCA graft rejection in human subjects or banked human specimens and medical records suitable for use in the clinic or at home
- Develop assays or devices for clinical implementation of graft monitoring utilizing validated biomarkers
Applications submitted to the FY22 RTRP Clinical Network Award must address the standardization, assessment, and validation of protocols and/or clinical practice guidelines (CPGs) for each of the following aspects of VCA for face and hand transplantation:
- Patient inclusion/exclusion criteria
- Patient education
- Surgical procedures
- Immunosuppression and/or immunoregulation
- Outcome metrics
- Quality-of-life measures
- Rehabilitation
- Patient reporting (e.g., registry)
Award Mechanism | Eligibility | Key Mechanism Elements | Funding |
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Investigator-Initiated Research Award | Independent investigators at all academic levels (or equivalent). |
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Single PI:
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Advanced Technology Development Award | Independent investigators at all academic levels (or equivalent). |
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Single PI:
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Concept Award | Independent investigators at all academic levels (or equivalent). |
|
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Clinical Network Award | Independent investigators at or above the level of Assistant Professor (or equivalent) are eligible to be named PI. |
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Phase I:
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A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final funding opportunity announcements that will be available for downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.
Submission deadlines are not available until the funding opportunity announcements are released. For email notification when program announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about the RTRP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.health.mil).
Point of Contact:
CDMRP Public Affairs
301-619-9783
usarmys.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@mail.mil
Last updated Thursday, December 5, 2024