DEPARTMENT OF DEFENSE - CONGRESSIONALLY DIRECTED MEDICAL RESEARCH PROGRAMS
  1. Home
  2. Research Programs
  3. Peer Review Alzheimer's
  4. Research Highlights/News
  5. 2025 Peer Reviewed Alzheimer's Research Program

NEWS RELEASE

Released: November 7, 2024

Department of Defense
Congressionally Directed Medical Research Programs (CDMRP)
Peer Reviewed Alzheimer's Research Program
Anticipated Funding Opportunities for Fiscal Year 2025 (FY25)

The FY25 Defense Appropriations Bill has not been signed into law. The CDMRP is unable to release new funding opportunities under the current Continuing Resolution. The CDMRP is providing pre-announcement information to allow investigators time to plan and develop ideas for submission to anticipated funding opportunities should the CDMRP receive FY25 appropriations. Pre-announcements should not be construed as an obligation or promise by the government. Once funding is available, CDMRP funding opportunities will be posted on the Grants.gov website. Pre-application and application deadlines will be available when opportunities are released, contingent upon future funding.

The FY25 Defense Appropriations Act is anticipated to provide funding for the Peer Reviewed Alzheimer's Research Program (PRARP) to support impactful, solution-oriented research to address critical needs and improve the quality of life for Service Members, Veterans, their Families, and the public who are living with Alzheimer's disease (AD) and related dementias (ADRD). The CDMRP at the U.S. Army Medical Research and Development Command (USAMRDC) is the program office managing these anticipated FY25 funding opportunities.

Applications submitted to the FY25 PRARP must be relevant to one or more of the following priority areas:

  • Reduce Risk and Prevent AD/ADRD
  • Improve Diagnosis and Prognosis
  • Improve Quality of Life for People Living With a Dementia Diagnosis

In addition, the PRARP is interested in work that addresses and reduces health disparities in AD/ADRD research.

All FY25 PRARP mechanisms have a Career Initiation or Transition (CIT) Partnership Option to encourage research capacity in critical areas to include women's health, military health and dementia care. The partnership option allows for two investigators with complementary research expertise to work collaboratively on one project. One investigator must meet the definition of Career Initiation or Career Transition. For this option, the CIT investigator should have only nominal research support in the field and be either:

(a) Career Initiation: a junior investigator three or more years from their terminal degree but no more than seven years into an independent position

(b) Career Transition: transitioning from another field to the AD/ADRD/TBI field and has only nominal, if any, publications in the AD-related field.
Award Mechanism Eligibility Key Mechanism Elements Funding
Transforming Care Award The PI must be an independent investigator at any career level.
  • Supports person-centered research that prioritizes both the individual with AD/ADRD and their care partner(s). The project should clearly demonstrate feasibility and a realistic approach to scaling and implementation.
  • "Care" does not refer to medical care (such as medical interventions administered by a physician) but is inclusive of all modalities and requirements of dementia care.
  • There is no requirement for studies to be performed in a Veteran or military cohort. The PRARP encourages investigators to consider how their research from a civilian cohort might be applicable to such populations, and vice versa.
  • Community collaboration is required for all applications.
  • Animal studies are not allowed.
  • Clinical trials are allowed.
  • The CIT Option is available.
  • Submission of a preproposal is required; application submission is by invitation only.
  • Maximum funding of $1.6 million (M) for total costs.
  • Maximum period of performance is 4 years.

CIT Option:

  • Maximum funding of $1.8M for total costs
Transforming Diagnosis Award The PI must be an independent investigator at any career level.
  • Supports research to reduce barriers and improve diagnosis and prognosis of dementia of AD/ADRD following military service and/or TBI.
  • There is no requirement for studies to be performed in a Veteran or military cohort. The PRARP encourages investigators to consider how their research from a civilian cohort might be applicable to such populations, and vice versa.
  • Studies leveraging existing cohorts or data sets are encouraged.
  • Community collaboration is required for all applications.
  • The CIT Option is available.
  • Animal studies are not allowed.
  • Submission of a preproposal is required; application submission is by invitation only.
  • Maximum funding of $1.5M for total costs.
  • Maximum period of performance is 4 years.

CIT Option:

  • Maximum funding of $1.7M for total costs
Transforming Research Award The PI must be an independent investigator at any career level.
  • Research must address the priority area of "Reduce risk and prevent AD/ADRD."
  • Supports high-impact research aimed to identify, validate, and/or mitigate risk factors that may contribute to dementia onset.
  • Clinical trials are not supported, but studies with prospective human subjects' enrollment may be allowed.
    • Applications proposing clinical studies will require community collaboration.
  • Studies leveraging existing cohorts or data sets are encouraged.
  • Animal studies that are fully justified for relevance to human health are allowed.
    • Community collaboration is not required for projects that focus primarily on animal studies but is encouraged.
  • The CIT Option is available.
  • Submission of a preproposal is required; application submission is by invitation only.
  • Maximum funding of $1.0M for total costs.
  • Maximum period of performance is 3 years.

CIT Option:

  • Maximum funding of $1.0M for total costs

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final funding opportunity announcement that will be available for downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

Submission deadlines are not available until the funding opportunity announcements are released. For email notification when announcements are released, subscribe to program-specific news and updates under "Email Subscriptions" on the eBRAP homepage. For more information about the PRARP or other CDMRP-administered programs, please visit the CDMRP website (https://cdmrp.health.mil).


Point of Contact:

CDMRP Public Affairs
301-619-9783
usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@health.mil








Last updated Thursday, November 7, 2024