Amyotrophic Lateral Sclerosis
Research Resources
Animal Models
Mice
ALZForum ALS Mouse Model Database – Organized phenotypic information to facilitate comparisons between over 40 ALS mouse models.
European Mutant Mouse Archive – More than 8,700 mutant mouse strains and a limited number of rat mutant strains are available. Includes several ALS-relevant strains with mutations in FUS, Tardbp, OPTN, PFn1, SOD1, Setx, Sqstm1, Vapb, C9orf72 and others.
Mutant Mouse Resource & Research Center – NIH-funded mouse lines and embryonic stem cells, as well as related products and services.
Other Animals
Bloomington Drosophila Stock Center (BDSC) ALS Fly Models – Collects, maintains, and distributes Drosophila melanogaster strains for research. Includes strains with mutations in SOD1, Alsin, SETX, FUS, VAPB, ANG, TARDP, FIG4, OPTN, ATXN2, UBQLN2, PFN1, TAF15, and EWSR1. Also has multiple C9orf72-relevant mutant strains with different GGGCC expansions.
The Zebrafish Information Network (ZFIN) – A database resource for the laboratory use of zebrafish genetic models. Part of the Alliance of Genome Resources. Information on multiple ALS Zebrafish models, including SOD1, FUS, and TARDBP mutants.
Alliance of Genome Resources – A consortium of seven model organism databases and the Gene Ontology Consortium. The Alliance includes FlyBase, The Mouse Genome Database, The Gene Ontology Consortium, The Saccharomyces Genome Database, The Rat Genome Database, WormBase, Xenbase, and The Zebrafish Information Network.