Animal Models

Mice

ALZForum ALS Mouse Model Database – Organized phenotypic information to facilitate comparisons between over 40 ALS mouse models.

European Mutant Mouse Archive (EMMA) – 8,000 mutant mouse lines cryopreserved as frozen sperm and/or embryos. Includes several ALS-relevant strains with mutations in FUS, Tardbp, OPTN, and others.

Jackson Labs ALS Mouse Model Resource – The Jackson Laboratory’s website to identify and select ALS mouse models and to find multiple helpful resources.

Mutant Mouse Resource & Research Center – NIH-funded mouse lines and embryonic stem (ES) cells, as well as related products and services.

Other Animals

Bloomington Drosophila Stock Center (BDSC) ALS Fly Models – Collects, maintains, and distributes Drosophila melanogaster strains for research. Includes strains with mutations in SOD1, Alsin, SETX, FUS, VAPB, ANG, TARDP, FIG4, OPTN, ATXN2, UBQLN2, PFN1, TAF15, and EWSR1. Also has multiple C9orf72-relevant mutant strains with different GGGCC expansions.

The Zebrafish Information Network (ZFIN) – A database resource for the laboratory use of zebrafish genetic models. Part of the Alliance of Genome Resources. Information on multiple ALS Zebrafish models, including SOD1 and TARDBP mutants.

Alliance of Genome Resources – A consortium of 6 model organism databases and the Gene Ontology (GO) Consortium whose goal is to provide an integrated view of their data in order to facilitate the use of diverse model organisms in understanding the genetic and genomic basis of human biology, heath, and disease. The Alliance includes FlyBase, The Mouse Genome Database, The Gene Ontology Consortium, The Saccharomyces Genome Database, The Rat Genome Database, WormBase, and The Zebrafish Information Network.